Genomic African and Native American Ancestry and 15‐Year Cognitive Trajectory: Bambui Study, Brazil

Objectives To investigate the association between African and Native American genomic ancestry and long‐term cognitive trajectories in admixed Brazilians. Design Population‐based longitudinal study. Setting Bambui‐Epigen (Brazil) cohort study. Participants Adults aged 60 and older (N=1,215) Measurem...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2018-10, Vol.66 (10), p.1956-1962
Main Authors: Lima‐Costa, M. Fernanda, Gouveia, Mateus H., Cesar, Cibele C., Tarazona‐Santos, Eduardo, Stewart, Rob, Ferri, Cleusa P., Castro‐Costa, Erico
Format: Article
Language:English
Subjects:
ancestry
Cognitive ability
education
ethnicity
Genomes
Longitudinal studies
longitudinal study
Mini‐Mental State Examination
Minority & ethnic groups
Population studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To investigate the association between African and Native American genomic ancestry and long‐term cognitive trajectories in admixed Brazilians. Design Population‐based longitudinal study. Setting Bambui‐Epigen (Brazil) cohort study. Participants Adults aged 60 and older (N=1,215) Measurements Participants were followed from January 1997 to December 2011. Cognitive function was assessed annually using the Mini‐Mental State Examination (MMSE), totaling 12,208 measurements. We used linear mixed‐effects pattern models to assess MMSE score trajectories. Ancestry was assessed using a genome‐wide approach. Results After adjustments for covariates, the highest quintile of African ancestry was associated with poorer baseline cognitive performance (β=–0.73, 95% confidence interval (CI)=–1.36 to –0.11) but not with cognitive trajectory. Educational level modified the baseline association between highest African ancestry and cognitive performance in that the association was observed only in those with very low (
ISSN:0002-8614
1532-5415
DOI:10.1111/jgs.15504