Fabrication of Zn-Sr–doped laser-spinning glass nanofibers with antibacterial properties

The morphology and dimensions of bioactive materials are essential attributes to promote tissue culture. Bioactive materials with nanofibrous structure have excellent potential to be used as bone-defect fillers, since they mimic the collagen in the extracellular matrix. On the other hand, bioactive...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomaterials applications 2017-01, Vol.31 (6), p.819-831
Main Authors: Echezarreta-López, María Magdalena, de Miguel, Trinidad, Quintero, Félix, Pou, Juan, Landín, Mariana
Format: Article
Language:English
Subjects:
Antibacterial properties
Bacteria
Biocompatibility
Biomaterials
Glass
Morphology
Nanofibers
Staphylococcus aureus
Zinc
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The morphology and dimensions of bioactive materials are essential attributes to promote tissue culture. Bioactive materials with nanofibrous structure have excellent potential to be used as bone-defect fillers, since they mimic the collagen in the extracellular matrix. On the other hand, bioactive glasses with applications in regenerative medicine may present antibacterial properties, which depend on glass composition, concentration and the microorganisms tested. Likewise, their morphology may influence their antibacterial activity too. In the present work, the laser-spinning technique was used to produce bioactive glass nanofibers of two different compositions: 45S5 Bioglass® and ICIE16M, bioactive glass doped with zinc and strontium. Their antibacterial activity against Staphylococcus aureus was tested by culturing them in dynamic conditions. Bacterial growth index profiles during the first days of experiment can be explained by the variations in the pH values of the media. The bactericidal effect of the doped nanofibers at longer times is justified by the release of zinc and strontium ions. Cytotoxicity was analyzed by means of cell viability tests performed with BALB/3T3 cell line.
ISSN:0885-3282
1530-8022
DOI:10.1177/0885328216684652