Synthesis and Biophysical Characterization of G-Rich Oligonucleotides Conjugated with Sugar-Phosphate Tails

A number of 5′-and 3′-glycoconjugates of the oligonucleotide 5 ′d(TGGGAG) 3 ′ have been synthesized, exploiting fully automated, online phosphoramidite-based solid phase strategy, as potential anti-HIV-1 agents. The thermodynamic stability of the resulting quadruplexes has been investigated by therm...

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Bibliographic Details

Published in:	Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2007-01, Vol.26 (10-12), p.1225-1229
Main Authors:	D'Onofrio, J., Erra, E., Fabio, G. Di, Iadonisi, A., Petraccone, L., Napoli, L. De, Barone, G., Balzarini, J., Giancola, C., Montesarchio, D.
Format:	Article
Language:	English
Subjects:	Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry anti-HIV-1 agents Conjugated oligonucleotides G-quadruplex structures sugar-phosphate tails Glycoconjugates - chemical synthesis Glycoconjugates - chemistry Guanosine - genetics HIV-1 Oligodeoxyribonucleotides - chemical synthesis Oligodeoxyribonucleotides - chemistry Sugar Phosphates - chemistry
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