Antibiotics: a risk factor for irritable bowel syndrome in a population-based cohort

Objectives: Use of antibiotics affects the composition of the gut microbiome. The microbiome is thought to play a role in development of irritable bowel syndrome (IBS), but antibiotics as a possible risk factor for IBS has not been clarified. We aimed to explore if antibiotics is a risk factor for I...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2018-09, Vol.53 (9), p.1027-1030
Main Authors: Krogsgaard, Laura Rindom, Engsbro, Anne Line, Bytzer, Peter
Format: Article
Language:English
Subjects:
abdominal pain
Adolescent
Adult
Anti-bacterial agents
Anti-Bacterial Agents - adverse effects
Asymptomatic Diseases - epidemiology
Cohort Studies
Denmark - epidemiology
Drug Utilization - statistics & numerical data
Female
functional bowel disorders
Gastrointestinal Microbiome - drug effects
Humans
Irritable Bowel Syndrome - chemically induced
Irritable Bowel Syndrome - epidemiology
Logistic Models
Male
microbiome
microbiota
Middle Aged
Risk Factors
Surveys and Questionnaires
Young Adult
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Summary:Objectives: Use of antibiotics affects the composition of the gut microbiome. The microbiome is thought to play a role in development of irritable bowel syndrome (IBS), but antibiotics as a possible risk factor for IBS has not been clarified. We aimed to explore if antibiotics is a risk factor for IBS by investigating use of antibiotics and development of IBS in a cohort from the Danish background population. Materials and Methods: An internet-based web panel representative of the Danish background population was invited to participate in a survey regarding the epidemiology of IBS in 2010, 2011 and 2013. A questionnaire based on the Rome III criteria for IBS were answered at all three occasions. In 2013, a question regarding use of antibiotics in the past year was included. Results: In 2013, use of antibiotics was reported by 22.4% (624/2781) of the population. A higher proportion of individuals with IBS reported use of antibiotics compared with asymptomatic controls [29.0% (155/534) vs. 17.9% (212/1,184), p 
ISSN:0036-5521
1502-7708
DOI:10.1080/00365521.2018.1500638