Patient characteristics of olfactory neuroblastoma: experience from a tertiary cancer centre 2000–2016 covering Eastern Denmark

The aim of this study was to report incidence and patient characteristics of olfactory neuroblastoma (ONB) at a tertiary cancer institution during a 16‐year period. A retrospective review was conducted on patients with ONB treated at Rigshospitalet, Copenhagen from 2000 to 2016 covering Eastern Denm...

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Bibliographic Details
Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2018-08, Vol.126 (8), p.663-666
Main Authors: Gram, Signe Buhl, Grønhøj, Christian, Mann, Henriette, Jakobsen, Kathrine Kronberg, Kiss, Katalin, Bilde, Anders, Buchwald, Christian
Format: Article
Language:English
Subjects:
Adolescent
Adult
aesthesioneuroblastoma
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer
Chemotherapy
Demographics
Demography
Denmark
ectopic olfactory neuroblastoma
Esthesioneuroblastoma, Olfactory - mortality
Esthesioneuroblastoma, Olfactory - pathology
Esthesioneuroblastoma, Olfactory - surgery
Esthesioneuroblastoma, Olfactory - therapy
Female
Females
Gamma Rays - therapeutic use
Hospitals, University
Humans
Male
Males
Middle Aged
Nasal Cavity - drug effects
Nasal Cavity - pathology
Nasal Cavity - radiation effects
Nasal Cavity - surgery
Neoplasm Grading
Neoplasm Staging
Neuroblastoma
Nose Neoplasms - mortality
Nose Neoplasms - pathology
Nose Neoplasms - surgery
Nose Neoplasms - therapy
Olfactory neuroblastoma
Pathology
Patients
Prognosis
Radiation therapy
Rare diseases
Registries
Retrospective Studies
Surgery
Survival Analysis
Tumors
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Summary:The aim of this study was to report incidence and patient characteristics of olfactory neuroblastoma (ONB) at a tertiary cancer institution during a 16‐year period. A retrospective review was conducted on patients with ONB treated at Rigshospitalet, Copenhagen from 2000 to 2016 covering Eastern Denmark. Patient demographics, symptoms, stage, pathology‐reports, treatment, and outcome were extracted from the patient records and the Danish pathology register. The tumours were graded both histologically and clinically using Hyam's and Kadish classifications, respectively. We identified a total of 14 patients (ten males, four females, median age 57 years, range 17–81 years). Four patients were in Kadish stage A, one stage B, and seven stage C. According to Hyam's classification, two tumours were grade I, nine grade II, and three grade III. All patients were treated with surgery, eight in combination with radiotherapy, where one received proton therapy, and one a combination with chemotherapy. At a median follow‐up time of 58 months, the 5‐year overall survival was 90% (95% CI 61; 99). ONB is a rare disease; complete radical surgery alone or combined with radiotherapy offered good oncologic control and outcome. Long‐term follow‐up of ONB should be mandatory.
ISSN:0903-4641
1600-0463
DOI:10.1111/apm.12859