New Insights into the Role of Exosomes in the Heart After Myocardial Infarction

Intercellular communications play a pivotal role in several cardiac pathophysiological processes. One subtype of extracellular vesicles, so-called exosomes, became known as important intercellular communication mediators in the heart. Exosomes are lipid bilayer biological nanovesicles loaded with di...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiovascular translational research 2019-02, Vol.12 (1), p.18-27
Main Authors: Li, Na, Rochette, Luc, Wu, Yongxin, Rosenblatt-Velin, Nathalie
Format: Article
Language:English
Subjects:
Animals
Biomedical Engineering and Bioengineering
Biomedicine
Cardiology
Cell Communication
Cell Proliferation
Exosomes - genetics
Exosomes - metabolism
Exosomes - pathology
Exosomes - transplantation
Gene Expression Regulation
Human Genetics
Humans
Medicine
Medicine & Public Health
Myocardial Infarction - metabolism
Myocardial Infarction - pathology
Myocardial Infarction - physiopathology
Myocardial Infarction - surgery
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Myocytes, Cardiac - transplantation
Recovery of Function
Regeneration
Review
Signal Transduction
Stem Cell Transplantation - methods
Stem Cells - metabolism
Stem Cells - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intercellular communications play a pivotal role in several cardiac pathophysiological processes. One subtype of extracellular vesicles, so-called exosomes, became known as important intercellular communication mediators in the heart. Exosomes are lipid bilayer biological nanovesicles loaded with diverse proteins, lipids, and mRNAs/microRNAs. All major cardiac cell types can modulate recipient cellular function via the release of exosomes. After myocardial infarction (MI), exosomes, especially those secreted by different cardiac stem cells, have been shown to confer cardioprotective effects, activate regenerative signals, and participate into cardiac repair. In this review, we rapidly recall the biology of exosomes at the beginning. Then we summarize the exosomes secreted by different myocardial cells and their function in cardiac intercellular communication. At last, we discuss the role of these vesicles in cardiac repair after MI.
ISSN:1937-5387
1937-5395
DOI:10.1007/s12265-018-9831-z