Echocardiographic evolution of left ventricular function in childhood leukemia survivors

Cardiac events are the most common nonmalignant cause of death in childhood cancer survivors. This population has an increased risk of morbimortality, probably secondary to the treatment side effects. The objective was to determine the prevalence and determinants of left ventricular dysfunction in a...

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Bibliographic Details
Published in:Current problems in cancer 2018-07, Vol.42 (4), p.397-408
Main Authors: Aznar, Elena Guadalupe Corella, Casas, Ariadna Ayerza, Escribano, Maria Ángeles Carlota Calvo, Montañés, Lorenzo Jiménez, Aizpún, José Ignacio Labarta, Villagrasa, Pilar Samper
Format: Article
Language:English
Subjects:
Acute leukemia
Adolescent
Antineoplastic Agents - adverse effects
Bi-dimensional echocardiography
Cardiotoxicity - diagnosis
Cardiotoxicity - etiology
Child
Child, Preschool
Childhood cancer survivors
Echocardiography - methods
Female
Fractional shortening
Humans
Infant
Left ventricular ejection fraction
Leukemia - drug therapy
Male
Prognosis
Retrospective Studies
Risk Factors
Survivors - statistics & numerical data
Ventricular Function, Left - drug effects
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Summary:Cardiac events are the most common nonmalignant cause of death in childhood cancer survivors. This population has an increased risk of morbimortality, probably secondary to the treatment side effects. The objective was to determine the prevalence and determinants of left ventricular dysfunction in a cohort of long term childhood acute leukemia survivors treated with potentially cardiotoxic therapies. Retrospective study with at least 10 years of follow-up, diagnosed between 1999 and 2003. The reduction percentage of the fractional shortening and ejection fraction was calculated from the diagnosis to the end of treatment and 10 years after the end of treatment. The factors associated with their decrease were analyzed. The fractional shortening and ejection fraction experienced a significant decrease 10 years after the end of treatment from 38.16 to 32 and 69.08 to 60.79, respectively. Reduction was more pronounced during the evaluation of the first year after treatment (−10.3% and −8.96%, P
ISSN:0147-0272
1535-6345
DOI:10.1016/j.currproblcancer.2018.07.012