Lavandulyl Flavanones from Sophora flavescens Protect Mouse Hippocampal Cells against Glutamate-Induced Neurotoxicity via the Induction of Heme Oxygenase-1

Lavandulyl flavanones of Sophora flavescens roots are anti-malarial, anti-inflammatory, and cytotoxic. Here, we examined whether four lavandulyl flavanones, (2S)-2′-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (−)-kurarinone (4), isolated from S. flavescens could protect HT2...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2008/10/01, Vol.31(10), pp.1964-1967
Main Authors: Jeong, Gil-Saeng, Li, Bin, Lee, Dong-Sung, Byun, Erisa, An, Ren-Bo, Pae, Hyun-Ock, Chung, Hun-Taeg, Youn, Kwon-Ha, Kim, Youn-Chul
Format: Article
Language:English
Subjects:
Animals
Blotting, Western
Cell Line
Cell Survival - drug effects
cytoprotection
Dose-Response Relationship, Drug
Enzyme Induction - drug effects
Excitatory Amino Acid Agonists - toxicity
Flavanones - isolation & purification
Flavanones - pharmacology
glutamate
Glutamic Acid - toxicity
heme oxygenase-1
Heme Oxygenase-1 - biosynthesis
Hippocampus - cytology
Hippocampus - drug effects
HT22
lavandulyl flavanone
Mice
Neuroprotective Agents - isolation & purification
Neuroprotective Agents - pharmacology
Oxidative Stress - drug effects
Reactive Oxygen Species - metabolism
Sophora
Sophora - chemistry
Sophora flavescens
Up-Regulation - drug effects
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Summary:Lavandulyl flavanones of Sophora flavescens roots are anti-malarial, anti-inflammatory, and cytotoxic. Here, we examined whether four lavandulyl flavanones, (2S)-2′-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (−)-kurarinone (4), isolated from S. flavescens could protect HT22 immortalized hippocampal cells against glutamate-induced oxidative stress. Compounds 1 and 2 induced the expression of heme oxygenase (HO)-1 and increased HO activity dose- and time-dependently. These two compounds also suppressed glutamate-induced reactive oxygen species generation in HT22 cells, whereas compounds 3 and 4 were not protective. These two lavandulyl flavanones (compounds 1, 2) may protect against glutamate-induced neurotoxicity via HO-1 induction.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.31.1964