The emergence of Zika virus and its new clinical syndromes

Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health threat because of its potential to generate explosive epidemics and ability to cause congenital disease in the context of infection during pregnancy. Whereas much is known about the biology of related flavivir...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 2018-08, Vol.560 (7720), p.573-581
Main Authors: Pierson, Theodore C, Diamond, Michael S
Format: Article
Language:English
Subjects:
Animal models
Animals
Aquatic insects
Biology
Cell culture
Clinical trials
Congenital diseases
Disease Models, Animal
Disease transmission
Epidemics
Fetuses
Genetic disorders
Global health
Health
Health aspects
Health risks
Humans
Immune privilege
Infection
Infections
Knowledge
Medical research
Medical schools
Pathogenesis
Pregnancy
Sexual transmission
Syndrome
Vaccines
Vector-borne diseases
Viral Vaccines - immunology
Viruses
Zika virus
Zika Virus - chemistry
Zika Virus - genetics
Zika Virus - immunology
Zika Virus - pathogenicity
Zika Virus Infection - congenital
Zika Virus Infection - epidemiology
Zika Virus Infection - immunology
Zika Virus Infection - virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health threat because of its potential to generate explosive epidemics and ability to cause congenital disease in the context of infection during pregnancy. Whereas much is known about the biology of related flaviviruses, the unique features of ZIKV pathogenesis, including infection of the fetus, persistence in immune-privileged sites and sexual transmission, have presented new challenges. The rapid development of cell culture and animal models has facilitated a new appreciation of ZIKV biology. This knowledge has created opportunities for the development of countermeasures, including multiple ZIKV vaccine candidates, which are advancing through clinical trials. Here we describe the recent advances that have led to a new understanding of the causes and consequences of the ZIKV epidemic.
ISSN:0028-0836
1476-4687
DOI:10.1038/s41586-018-0446-y