Evaluation of the Anti-inflammatory, Analgesic and Antipyretic Activities of the Natural Polyphenol Chlorogenic Acid

Phenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA)...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2006, Vol.29(11), pp.2236-2240
Main Authors: Santos, Michel David dos, Almeida, Maria Camila, Lopes, Norberto Peporine, Glória Emília Petto de Souza
Format: Article
Language:eng ; jpn
Subjects:
Administration, Oral
analgesic
Analgesics - administration & dosage
Analgesics - chemistry
Analgesics - therapeutic use
Analgesics, Non-Narcotic - administration & dosage
Analgesics, Non-Narcotic - chemistry
Analgesics, Non-Narcotic - therapeutic use
Animals
anti-inflammatory
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Carrageenan - administration & dosage
Carrageenan - toxicity
carrageenin
chlorogenic acid
Chlorogenic Acid - administration & dosage
Chlorogenic Acid - chemistry
Chlorogenic Acid - therapeutic use
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical - methods
Edema - chemically induced
Edema - prevention & control
Fever - chemically induced
Fever - prevention & control
Flavonoids - administration & dosage
Flavonoids - chemistry
Flavonoids - therapeutic use
Formaldehyde - administration & dosage
Formaldehyde - toxicity
formalin
Hindlimb - drug effects
Hindlimb - pathology
Hindlimb - physiopathology
Inflammation - chemically induced
Inflammation - prevention & control
lipopolysaccharide (LPS)
Lipopolysaccharides - administration & dosage
Lipopolysaccharides - toxicity
Male
Molecular Structure
Pain - chemically induced
Pain - prevention & control
Phenols - administration & dosage
Phenols - chemistry
Phenols - therapeutic use
Polyphenols
Rats
Rats, Wistar
Time Factors
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Summary:Phenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in human diet. Data obtained from in vivo and in vitro experiments show that CGA mostly presents antioxidant and anti-carcinogenic activities. However, the effects of CGA on the inflammatory reaction and on the related pain and fever processes have been explored less so far. Therefore, this study was designed to evaluate the anti-inflammatory, antinociceptive and antipyretic activities of CGA in rats. In comparison to control, CGA at doses 50 and 100 mg/kg inhibited carrageenin-induced paw edema beginning at the 2nd hour of the experimental procedure. Furthermore, at doses 50 and 100 mg/kg CGA also inhibited the number of flinches in the late phase of formalin-induced pain test. Such activities may be derived from the inhibitory action of CGA in the peripheral synthesis/release of inflammatory mediators involved in these responses. On the other hand, even at the highest tested dose (200 mg/kg), CGA did not inhibit the febrile response induced by lipopolysaccharide (LPS) in rats. Additional experiments are necessary in order to clarify the true target for the anti-inflammatory and analgesic effects of CGA.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.29.2236