Analytical quality goals—a review

Analytical quality goals indicate how laboratory tests must perform to be clinically useful for their intended purpose. These goals have historically focused on analytical error assessment for quantitative methods and vary with measurand concentration or activity, and species. Although formalized qu...

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Bibliographic Details
Published in:Veterinary clinical pathology 2018-12, Vol.47 (4), p.527-538
Main Authors: Flatland, Bente, Camus, Melinda S., Baral, Randolph M.
Format: Article
Language:English
Subjects:
Allowable total error
biological variation
Error analysis
Historical account
Laboratories
Measurement methods
Quality
quality control
quality requirement
quality specification
TEA
Veterinary medicine
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Summary:Analytical quality goals indicate how laboratory tests must perform to be clinically useful for their intended purpose. These goals have historically focused on analytical error assessment for quantitative methods and vary with measurand concentration or activity, and species. Although formalized quality goal models have been developed in human medicine, quality goals in veterinary medicine, to date, have not been formalized; use of human regulatory‐based goals, consensus‐based goals, or biologic variation‐based goals have been reported most often. This review provides an overview of how quality goals are derived, how these may be used, and highlights challenges. Pending formal recommendations, individual veterinary laboratories should select quality goals that make the most sense clinically, logistically, and financially based on their individual needs and the needs of the clients that they serve.
ISSN:0275-6382
1939-165X
DOI:10.1111/vcp.12649