Cardiac autonomic dysfunction in rats chronically treated with anabolic steroid

To date no published data exist regarding the effects of chronic high-dose anabolic-androgenic steroid administration on tonic cardiac autonomic control. The aim of this study was to evaluate, by power spectral analysis of heart rate variability (HRV), the effects of chronic treatment with supraphys...

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Bibliographic Details
Published in:European journal of applied physiology 2006-03, Vol.96 (5), p.487-494
Main Authors: Pereira-Junior, Pedro P, Chaves, Elen A, Costa-E-Sousa, Ricardo H, Masuda, Masako O, de Carvalho, Antonio C Campos, Nascimento, José H M
Format: Article
Language:English
Subjects:
Anabolic Agents - pharmacology
Animals
Autonomic Nervous System Diseases - chemically induced
Body Weight - drug effects
Consciousness
Electrocardiography
Heart - innervation
Heart Rate - drug effects
Male
Nandrolone - analogs & derivatives
Nandrolone - pharmacology
Organ Size - drug effects
Rats
Rats, Wistar
Rodents
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Summary:To date no published data exist regarding the effects of chronic high-dose anabolic-androgenic steroid administration on tonic cardiac autonomic control. The aim of this study was to evaluate, by power spectral analysis of heart rate variability (HRV), the effects of chronic treatment with supraphysiological doses of nandrolone decanoate (DECA) on tonic cardiac autonomic regulation in sedentary rats. Male Wistar rats were treated weekly with 10 mg kg(-1) of DECA (n=7) or vehicle (CONTROL, n=7) for 10 weeks. At the 8th week of treatment, electrocardiogram was recorded in the conscious state, for time- and frequency-domain HRV analysis. Parasympathetic indexes were reduced in DECA group: high-frequency power (CONTROL=11.1+/-3.0 ms2 vs. DECA=3.8+/-0.6 ms2, P
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-005-0111-7