Utility and limitations of noninvasive fibrosis markers for predicting prognosis in biopsy‐proven Japanese non‐alcoholic fatty liver disease patients

Background and Aim The fibrosis stage of non‐alcoholic fatty liver disease (NAFLD) is closely associated with long‐term prognosis, including liver‐related mortality. However, it is not yet clear whether noninvasive fibrosis markers can predict the incidence of non‐liver‐related complications in Japa...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2019-01, Vol.34 (1), p.207-214
Main Authors: Ito, Takanori, Ishigami, Masatoshi, Ishizu, Yoji, Kuzuya, Teiji, Honda, Takashi, Hayashi, Kazuhiko, Nishimura, Daisaku, Toyoda, Hidenori, Kumada, Takashi, Goto, Hidemi, Hirooka, Yoshiki
Format: Article
Language:English
Subjects:
Adult
Age Factors
Alanine Transaminase - blood
Aspartate Aminotransferases - blood
Bile
Bilirubin
Biopsy
Blood Glucose - metabolism
Body Mass Index
Carcinoma, Hepatocellular - epidemiology
Carcinoma, Hepatocellular - mortality
Cardiovascular Diseases - epidemiology
Cirrhosis
Fatty liver
Female
Fibrosis
FIB‐4 index
Hepatocellular carcinoma
Humans
Incidence
Japan - epidemiology
Liver cancer
Liver cirrhosis
Liver Cirrhosis - blood
Liver Cirrhosis - complications
Liver Cirrhosis - mortality
Liver Cirrhosis - pathology
Liver diseases
liver fibrosis
Liver Neoplasms - epidemiology
Liver Neoplasms - mortality
Male
Medical prognosis
Middle Aged
NAFLD
NFS
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - mortality
Platelet Count
Predictive Value of Tests
Prognosis
Risk factors
Severity of Illness Index
Survival
Survival Rate
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Summary:Background and Aim The fibrosis stage of non‐alcoholic fatty liver disease (NAFLD) is closely associated with long‐term prognosis, including liver‐related mortality. However, it is not yet clear whether noninvasive fibrosis markers can predict the incidence of non‐liver‐related complications in Japanese NAFLD. In this study, we clarified the prognosis of NAFLD patients, including non‐liver‐related diseases, based on hepatic pathology and noninvasive fibrosis markers. Methods A total of 246 Japanese patients with NAFLD diagnosed by liver biopsy were enrolled. We investigated their prognosis based on hepatic pathology and noninvasive fibrosis markers. Results When these patients were categorized based on the severity of liver fibrosis as F0–2 (n = 196) and F3–4 (n = 50), the patients with F3–4 had significantly poorer prognosis in overall survival rates and all complications (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.14448