The effects of high-intensity interval training on reverse cholesterol transport elements: A way of cardiovascular protection against atherosclerosis

Reverse cholesterol transport (RCT) is a process that prevents atherosclerosis. Studies showed that exercise training for strengthening cardiac muscle, increasing heart lipid metabolism and its potency against risk factors could protect cardiovascular health. Thus, the present study aims to investig...

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Bibliographic Details
Published in:Life sciences (1973) 2018-09, Vol.209, p.377-382
Main Authors: Rahmati-Ahmadabad, Saleh, Shirvani, Hossein, Ghanbari-Niaki, Abbass, Rostamkhani, Fatemeh
Format: Article
Language:English
Subjects:
ABCA1 protein
Animals
Arteriosclerosis
Atherosclerosis
Atherosclerosis - genetics
Atherosclerosis - metabolism
Atherosclerosis - prevention & control
ATP Binding Cassette Transporter, Sub-Family G, Member 1 - genetics
ATP Binding Cassette Transporter, Sub-Family G, Member 1 - metabolism
ATP-binding cassette transporter A1 (ABCA1)
ATP-binding protein
Cardiac muscle
Cardioprotection
Cardiovascular diseases
Cholesterol
Cholesterol - metabolism
Exercise
Gene expression
Gene Expression Regulation
Health risks
Heart
High density lipoprotein
High intensity interval training (HIIT)
High-Intensity Interval Training
Intestine
Intestines - metabolism
Lecithin–cholesterol acyltransferase (LCAT)
Lipid metabolism
Lipids
Liver
Liver - metabolism
Liver X receptor (LXR)
Liver X Receptors - genetics
Liver X Receptors - metabolism
Male
Metabolism
mRNA
Muscles
Oxygen Consumption
Phosphatidylcholine-Sterol O-Acyltransferase - genetics
Phosphatidylcholine-Sterol O-Acyltransferase - metabolism
Rats
Rats, Wistar
Reverse cholesterol transport (RCT)
Risk analysis
Risk factors
Rodents
Scavenger receptor class b member 1 (SR-BI)
Tissues
Training
Transport
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Summary:Reverse cholesterol transport (RCT) is a process that prevents atherosclerosis. Studies showed that exercise training for strengthening cardiac muscle, increasing heart lipid metabolism and its potency against risk factors could protect cardiovascular health. Thus, the present study aims to investigate the effects of high intensity interval training (HIIT) on RCT and its related elements in plasma and tissues (liver and intestine) of rats. Twenty adult male Wistar rats were randomly divided into control (n = 10) and trained (n = 10) groups. The trained group undertook HIIT (90%–95% of VO2max, five days/week, for 10 weeks) on a treadmill. The rats were killed five days after the last training session to minimize the effects of the last training session. A higher and significant ABCA1 mRNA was observed in the liver and intestine of trained rats. However, ABCG1 and LXR expressions only increased in the liver following the HIIT. These changes in the expression of the trained rats were accompanied by higher changes in plasma LCAT and HDL levels. The responses of ABCA1, as a key player in plasma HDL biogenesis, are similar in liver and intestine tissues after the HIIT program. However, different responses of ABCG1 and LXR in the liver and intestine tissues of the trained rats confirm the main role of the liver than the intestine in HDL biogenes. Therefore, HIIT modality result in cardiovascular protection by increasing the expression of genes involved in RCT and biogenesis of HDL. [Display omitted]
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2018.08.036