Chikungunya in solid organ transplant recipients, a case series and literature review

Chikungunya virus is a recent emerging arbovirus in Latin America, and the clinical manifestations can vary from fever and rash to severe chronic inflammatory arthritis. Few reports have been published regarding this infection in immunocompromised patients, including solid organ transplant recipient...

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Bibliographic Details
Published in:Transplant infectious disease 2018-12, Vol.20 (6), p.e12978-n/a
Main Authors: Rosso, Fernando, Rodríguez, Sarita, Cedano, Jorge A., Mora, Barbara L., Moncada, Pablo A., Velez, Juan D.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Arthralgia
Arthralgia - diagnosis
Arthralgia - epidemiology
Arthralgia - virology
Arthritis
Benign
Case reports
Chikungunya
Chikungunya Fever - diagnosis
Chikungunya Fever - epidemiology
Chikungunya Fever - virology
Chikungunya virus
Chikungunya virus - genetics
Chikungunya virus - isolation & purification
Child
Chronic infection
Colombia - epidemiology
Complications
Female
Fever
Graft rejection
Health risk assessment
Humans
Immunocompromised hosts
Immunosuppression
infection
Infections
Inflammation
Kidney transplantation
Kidney Transplantation - adverse effects
Kidney Transplantation - methods
Kidneys
Literature reviews
Liver
Liver transplantation
Liver Transplantation - adverse effects
Liver Transplantation - methods
Male
Middle Aged
Patients
Polymerase chain reaction
Recurrent infection
Reverse Transcriptase Polymerase Chain Reaction
Reverse transcription
RNA, Viral - isolation & purification
solid organ transplant
transplant recipients
Vector-borne diseases
Viruses
Young Adult
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Description
Summary:Chikungunya virus is a recent emerging arbovirus in Latin America, and the clinical manifestations can vary from fever and rash to severe chronic inflammatory arthritis. Few reports have been published regarding this infection in immunocompromised patients, including solid organ transplant recipients. We report a case series of solid organ transplant recipients with confirmed Chikungunya infection by positive reverse transcription polymerase chain reaction (RT‐PCR), identified between January 2014 and December 2016. In addition, we conducted a literature review searching PubMed, EMBASE, and LILACS databases on Chikungunya infection in solid organ transplant recipients. Ten solid organ transplant recipients were included, consisting of 5 kidney, 4 liver, and 1 liver/kidney transplant recipient. Mean age of the transplant recipients was 47 years, and the most frequent symptoms of Chikungunya infection were arthralgia and fever. None of the patients required treatment in the intensive care unit, no deaths or graft rejection occurred. None of our patients had recurrent arthritis during 3‐month follow‐up period after the infection. Twenty‐one cases of Chikungunya virus were identified in the literature review. Most cases had a benign clinical course with no severe complications, death, or chronic inflammatory arthritis. In conclusion, Chikungunya infection in solid organ transplant recipients has a benign course and has no chronic recurrent arthritis. It is possible that the immunosuppression regimen could decrease the risk of severe or chronic inflammatory manifestations in solid organ transplant recipients infected with Chikungunya.
ISSN:1398-2273
1399-3062
DOI:10.1111/tid.12978