Pragmatic abilities in multiple sclerosis: The contribution of the temporo-parietal junction

•Patients with multiple sclerosis show impaired pragmatic abilities.•We studied the neural basis of pragmatics in multiple sclerosis patients.•Results pointed to temporo-parietal junction and paracingulate connectivity.•Social communication involves a branched network over both hemispheres.•These fu...

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Bibliographic Details
Published in:Brain and language 2018-10, Vol.185, p.47-53
Main Authors: Carotenuto, Antonio, Cocozza, Sirio, Quarantelli, Mario, Arcara, Giorgio, Lanzillo, Roberta, Brescia Morra, Vincenzo, Cerillo, Ilaria, Tedeschi, Enrico, Orefice, Giuseppe, Bambini, Valentina, Brunetti, Arturo, Iodice, Rosa
Format: Article
Language:English
Subjects:
Brain
Comprehension
Functional connectivity
Functional magnetic resonance imaging
Geschwind’s area
Irony
Language
Metaphor
Multiple sclerosis
Neurological disorders
Neuropragmatics
Patients
Pragmatics
Social cognition
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Summary:•Patients with multiple sclerosis show impaired pragmatic abilities.•We studied the neural basis of pragmatics in multiple sclerosis patients.•Results pointed to temporo-parietal junction and paracingulate connectivity.•Social communication involves a branched network over both hemispheres.•These functional connections might be impaired in multiple sclerosis. Recent studies showed that multiple sclerosis (MS) patients might experience communicative deficits, specifically in pragmatics (i.e., the ability to integrate the context-dependent aspects of language). A crucial region for pragmatics is the temporo-parietal junction, in particular the so-called Geschwind’s area (GA), which is involved in high-level language processes, including the comprehension of narratives, metaphor, and irony. We evaluated the relationship between pragmatic abilities, measured through the Assessment of Pragmatic Abilities and Cognitive Substrates (APACS) test, and the functional connectivity (FC) of the bilateral GAs, assessed through a seed-based analysis of Resting-State fMRI in patients with MS. A positive correlation was observed between APACS scores and the FC for both the right and the left GA and the paracingulate cortex. Our findings suggest that the brain FC for social communication involves connections extending over both hemispheres, including right and left GAs and right and left paracingulate cortex, possibly impaired in patients with MS. This study offers preliminary evidence for future researches enrolling also a control sample to explore the involvement of GA in pragmatics in neurological disorders as well as in healthy conditions.
ISSN:0093-934X
1090-2155
DOI:10.1016/j.bandl.2018.08.003