Inducement of Sechenov inhibition by EtOH and NA in the Bufo toad

Central inhibition, discovered by Sechenov in 1862, suggests that electrically stimulating the forebrain or medulla oblongata in frog generally suppresses reflexes. However, the underlying molecular mechanisms are still unclear. Using ethanol （EtOH）, noradrenalin （NA）, and other neurotransmitters in...

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Bibliographic Details
Published in:Chinese science bulletin 2008-04, Vol.53 (8), p.1193-1196
Main Authors: Li, RuXin, Jia, ShanShan, Li, YingZi, Cao, Yin, Cheng, XiuZhen, Xie, ZuoPing
Format: Article
Language:English
Subjects:
Amphibia
Anura
Bufo
Chemistry/Food Science
Earth Sciences
Engineering
Humanities and Social Sciences
Life Sciences
multidisciplinary
Physics
Science
Science (multidisciplinary)
去甲肾上腺素
抑制作用
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Summary:Central inhibition, discovered by Sechenov in 1862, suggests that electrically stimulating the forebrain or medulla oblongata in frog generally suppresses reflexes. However, the underlying molecular mechanisms are still unclear. Using ethanol （EtOH）, noradrenalin （NA）, and other neurotransmitters in thalamic preparations, Sechenov inhibition was stimulated in Bufo toads in this study. The result showed that, similar to Sechenov inhibition, the acute application of EtOH or NA excited the thalamus and prolonged the latency of withdrawal reflex. Our study evidences the involvement of α-adrenoceptors in such central inhibition, and explains the role of acute EtOH application in the induction of reflex inhibition.
ISSN:1001-6538
2095-9273
1861-9541
2095-9281
DOI:10.1007/s11434-008-0189-5