Constant rate infusion vs. intermittent bolus administration of IV furosemide in 100 pets with acute left-sided congestive heart failure: A retrospective study

•Furosemide can be administered to dogs and cats with left-sided congestive heart failure (L-CHF) intravenously.•Constant rate infusion (CRI) and intravenous bolus (IVB) administration of furosemide in dogs and cats were compared.•CRI and IVB furosemide were associated with similar decreases in resp...

Full description

Saved in:
Bibliographic Details
Published in:The veterinary journal (1997) 2018-08, Vol.238, p.70-75
Main Authors: Ohad, D.G., Segev, Y., Kelmer, E., Aroch, I., Bdolah-Abram, T., Segev, G., Klainbart, S.
Format: Article
Language:English
Subjects:
Canine
Cat
Constant rate infusion
Dog
Feline
Furosemide
Intermittent bolus administration
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Furosemide can be administered to dogs and cats with left-sided congestive heart failure (L-CHF) intravenously.•Constant rate infusion (CRI) and intravenous bolus (IVB) administration of furosemide in dogs and cats were compared.•CRI and IVB furosemide were associated with similar decreases in respiratory rates of dogs and cats with L-CHF.•There was no short-term difference in mortality in dogs and cats receiving CRI or IVB furosemide.•CRI furosemide was associated with higher levels of dehydration and azotaemia than IVB furosemide. The aim of this study was to determine whether the addition of constant rate infusion (CRI) to intermittent intravenous bolus (IVB) administration of furosemide resulted in an improvement in medical outcomes in dogs and cats with acute left-sided congestive heart failure (L-CHF). A total of 76 client-owned dogs and 24 client-owned cats admitted with acute L-CHF were retrospectively divided between an IVB group (43 dogs and 16 cats) and a CRI group (33 dogs and 8 cats). The median furosemide dose used in dogs in the CRI group (median 0.99mg/kg/h; range 0.025–3.73mg/kg/h) was lower than the dose used in dogs in the IVB group (median 1.19mg/kg/h; range 0.027–7.14mg/kg/h; P=0.008). Respiratory rates were lower in the IVB group (P=0.005) and the CRI group (P=0.039) compared to pre-treatment values. The overall short-term mortality was 15%. A trend of longer hospitalisation in the IVB group relative to the CRI group (P=0.07) was shown. Creatinine and total plasma protein concentrations increased more in the CRI group than in the IVB group, suggestive of a higher risk of dehydration and azotaemia. There may be safety profile differences between CRI and IVB, warranting a prospective study using a larger sample size.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2018.07.001