Age-related changes in leukocytes and T cell subsets in peripheral blood of Japanese Black cattle

It is well known that the immune system changes with age during development and maturation in Holstein cattle. But age-related changes in leukocytes and T cell subsets in peripheral blood of Japanese Black cattle still remain unclear. The aim of the present study was to investigate comparative chang...

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Bibliographic Details
Published in:Animal science journal 2008-06, Vol.79 (3), p.368-374
Main Authors: Tanaka, S.(Tohoku Univ., Sendai (Japan)), Miyazawa, K, Kuwano, A, Watanabe, K, Ohwada, S, Aso, H, Nishida, S, Yamaguchi, T
Format: Article
Language:English
Subjects:
Age differences
AGING
BOVIN
CATTLE
CELL COUNTING
CELL MEDIATED IMMUNITY
Cellular biology
CONTEO DE CELULAS
ENVEJECIMIENTO
GANADO BOVINO
IMMUNITE
IMMUNITE CELLULAIRE
IMMUNITY
Immunology
INMUNIDAD
INMUNIDAD CELULAR
Japanese Black cattle
LEUCOCITOS
LEUCOCYTE
LEUKOCYTES
NUMERATION CELLULAIRE
T cell subsets
VIEILLISSEMENT
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Summary:It is well known that the immune system changes with age during development and maturation in Holstein cattle. But age-related changes in leukocytes and T cell subsets in peripheral blood of Japanese Black cattle still remain unclear. The aim of the present study was to investigate comparative changes of leukocytes (granulocytes, monocytes, B cells and T cells) and T cell subsets (CD4sup(+), CD8sup(+), gammadelta, CD8sup(+)gammadelta and WC1sup(+)gammadelta T cells) in Japanese Black cattle aged 0.5, 1, 2, 6, 18 and 36-41 (adult) months on flow cytometry using specific monoclonal antibodies for the cell surface markers. T cell proportion was approximately 40% in 2-month-old cattle and decreased to 20.6% in adults. In contrast, B cell proportion significantly increased from 7.4% to 28.2% with age. In T cell subsets the percentage of CD4sup(+) T cells significantly increased from 40.5% to 60%, but that of WC1sup(+)gammadelta T cell subset significantly decreased with age. The percentages of CD8sup(+) and CD8sup(+)gammadelta T cells did not change. The present study details the proportional changes in leukocyte and T cell subsets with age in the peripheral blood of Japanese Black cattle and these findings are similar to those described for Holstein cattle.
ISSN:1344-3941
1740-0929
DOI:10.1111/j.1740-0929.2008.00539.x