Both maternal care received and genotype influence stress‐related phenotype in female rats

Rat dams differ naturally in the level of maternal care they provide to their offspring within the same litter. We explored possible mechanisms of differential maternal care focused on genetic variation. We examined single nucleotide polymorphisms in the glucocorticoid receptor, FK506‐binding protei...

Full description

Saved in:
Bibliographic Details
Published in:Developmental psychobiology 2018-12, Vol.60 (8), p.889-902
Main Authors: Pan, Pauline, Lawson, Daeria O., Dudin, Aya, Vasquez, Oscar E., Sokolowski, Marla B., Fleming, Alison S., McGowan, Patrick O.
Format: Article
Language:English
Subjects:
anxiety
behavior
corticosterone
FK506‐binding protein
genotype
glucocorticoid receptor
hypothalamic–pituitary–adrenal Axis
maternal care
rat
serotonin
single nucleotide polymorphism
stress response
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rat dams differ naturally in the level of maternal care they provide to their offspring within the same litter. We explored possible mechanisms of differential maternal care focused on genetic variation. We examined single nucleotide polymorphisms in the glucocorticoid receptor, FK506‐binding protein, and serotonin transporter genes in two separate cohorts, and the relationship between differential maternal care received, genotype, and offspring phenotype. Allelic variation in all three genes was significantly associated with levels of maternal care received by offspring and behavioral and endocrine stress responses in adulthood. Differences in pup behavior were also associated with allelic variation in these genes. Together, these results indicate that the dam/pup interaction is dynamic and implicate the genotype of the offspring in influencing the level of maternal care received. They further suggest that some genotypes may have a dampening effect on the impact of maternal care on stress‐related phenotypes in adulthood.
ISSN:0012-1630
1098-2302
DOI:10.1002/dev.21770