Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1

Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF4:Yb3+,Er3+@NaGdF4 (UCNP) with peptides to achieve responsive UC emission enhance...

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Published in:Nanoscale 2018-08, Vol.10 (33), p.15632-15640
Main Authors: Zha, Shuai, Fung, Yan Ho, Chau, Ho-Fai, Ma, Ping'an, Lin, Jun, Wang, Jing, Chan, Lai Sheung, Zhu, Guang, Lung, Hong Lok, Wong, Ka-Leung
Format: Article
Language:English
Subjects:
Animals
Cell Line, Tumor
Emission
Epstein-Barr Virus Nuclear Antigens - metabolism
Erbium
Female
HeLa Cells
Herpesvirus 4, Human
Humans
Mice, Inbred BALB C
Mice, Nude
Molecular Imaging
Nanomaterials
Nanoparticles
Neoplasms - therapy
Neoplasms - virology
Peptides
Proteins
Upconversion
Ytterbium
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cited_by cdi_FETCH-LOGICAL-c315t-1612ee5d77a85a10f73bbcc0eff4830b114ccec6a1c4f9f0eb8f96c6fe03cc2a3
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container_end_page 15640
container_issue 33
container_start_page 15632
container_title Nanoscale
container_volume 10
creator Zha, Shuai
Fung, Yan Ho
Chau, Ho-Fai
Ma, Ping'an
Lin, Jun
Wang, Jing
Chan, Lai Sheung
Zhu, Guang
Lung, Hong Lok
Wong, Ka-Leung
description Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF4:Yb3+,Er3+@NaGdF4 (UCNP) with peptides to achieve responsive UC emission enhancement upon binding to a targeted protein - EBNA1. EBNA1 is a well-known viral latent protein for the EBV-associated cancer. Peptide-coating of the functionalized core-shell nanoparticle diminishes upconverted emission intensity drastically. However, the peptide-coated UCNP shows selective and responsive UC emission enhancement via aggregation with the targeted protein. This phenomenon paves a new way for UCNM in molecular imaging.
doi_str_mv 10.1039/c8nr05015e
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source Royal Society of Chemistry
subjects Animals
Cell Line, Tumor
Emission
Epstein-Barr Virus Nuclear Antigens - metabolism
Erbium
Female
HeLa Cells
Herpesvirus 4, Human
Humans
Mice, Inbred BALB C
Mice, Nude
Molecular Imaging
Nanomaterials
Nanoparticles
Neoplasms - therapy
Neoplasms - virology
Peptides
Proteins
Upconversion
Ytterbium
title Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1
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