Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1

Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF4:Yb3+,Er3+@NaGdF4 (UCNP) with peptides to achieve responsive UC emission enhance...

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Bibliographic Details
Published in:Nanoscale 2018-08, Vol.10 (33), p.15632-15640
Main Authors: Zha, Shuai, Fung, Yan Ho, Chau, Ho-Fai, Ma, Ping'an, Lin, Jun, Wang, Jing, Chan, Lai Sheung, Zhu, Guang, Lung, Hong Lok, Wong, Ka-Leung
Format: Article
Language:English
Subjects:
Animals
Cell Line, Tumor
Emission
Epstein-Barr Virus Nuclear Antigens - metabolism
Erbium
Female
HeLa Cells
Herpesvirus 4, Human
Humans
Mice, Inbred BALB C
Mice, Nude
Molecular Imaging
Nanomaterials
Nanoparticles
Neoplasms - therapy
Neoplasms - virology
Peptides
Proteins
Upconversion
Ytterbium
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Summary:Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF4:Yb3+,Er3+@NaGdF4 (UCNP) with peptides to achieve responsive UC emission enhancement upon binding to a targeted protein - EBNA1. EBNA1 is a well-known viral latent protein for the EBV-associated cancer. Peptide-coating of the functionalized core-shell nanoparticle diminishes upconverted emission intensity drastically. However, the peptide-coated UCNP shows selective and responsive UC emission enhancement via aggregation with the targeted protein. This phenomenon paves a new way for UCNM in molecular imaging.
ISSN:2040-3364
2040-3372
DOI:10.1039/c8nr05015e