Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition

Objectives To examine combined immunoprofiles of epidermal growth factor receptor (EGFR), CD44, and p16 in oropharyngeal squamous cell carcinoma (OPSCC) and to correlate them with radiotherapy treatment outcomes and clinicopathological parameters. Prognostic impact of the American Joint Committee on...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2018-10, Vol.47 (9), p.864-872
Main Authors: Gurin, Dominik, Slavik, Marek, Hermanova, Marketa, Shatokhina, Tetiana, Sana, Jiri, Kazda, Tomas, Selingerova, Iveta, Ahmad, Parwez, Smilek, Pavel, Horakova, Zuzana, Hendrych, Michal, Slampa, Pavel, Slaby, Ondrej
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - analysis
Biopsy
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - pathology
CD44
CD44 antigen
Clinical outcomes
combined immunoprofiles
Cyclin-Dependent Kinase Inhibitor p16 - analysis
Dentistry
EGFR
Epidermal growth factor
Epidermal growth factor receptors
ErbB Receptors - analysis
Female
Human papillomavirus
Humans
Hyaluronan Receptors - analysis
Immunohistochemistry
Male
Middle Aged
Neoplasm Staging - methods
OPSCC
Oropharyngeal Neoplasms - diagnosis
Oropharyngeal Neoplasms - pathology
p16
Patients
Prognosis
Radiation therapy
Squamous cell carcinoma
Throat cancer
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Summary:Objectives To examine combined immunoprofiles of epidermal growth factor receptor (EGFR), CD44, and p16 in oropharyngeal squamous cell carcinoma (OPSCC) and to correlate them with radiotherapy treatment outcomes and clinicopathological parameters. Prognostic impact of the American Joint Committee on Cancer (AJCC) 8th edition staging system in comparison with 7th edition was analyzed. Methods The study included 77 OPSCC patients treated by definitive intensity‐modulated radiotherapy (IMRT). Clinical staging was assessed according to the AJCC, both 7th and 8th edition. Immunohistochemical (IHC) analysis of CD44 and EGFR was performed on primary biopsy tumor tissues. To evaluate the HPV status, IHC detection of p16 was employed. Results The AJCC 8th edition staging system revealed correlations between overall survival (OS), progression‐free survival (PFS), locoregional control (LRC), and clinical stage. EGFR and CD44 positivity (+) and p16 negativity (−) were associated with clinical stage IV of the disease. CD44+ and EGFR+ OPSCC displayed worse OS and LRC, and these cases also showed the worst 3‐year OS and LRC. Combined analysis of protein expressions identified an association between p16− and EGFR+, p16− and CD44+, EGFR+, and CD44+. Combined immunoprofiles CD44+/p16−, EGFR+/p16−, and EGFR+/CD44+ were associated with worst OS and LRC. Conclusions Combined immunoprofiles of p16, EGFR, and CD44 might provide valuable prognostic and predictive information for the individual OPSCC patients, especially in terms of response to IMRT and prediction of treatment outcomes. Application of the AJCC 8th edition staging for HPV+ OPSCC proved to improve hazard discrimination and prognostication of OPSCC.
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.12772