Plasma Amino Acid Concentrations Are Associated with Muscle Function in Older Japanese Women

Background Although several previous studies have found benefits for amino acid supplementation in terms of muscle function, the role of plasma amino acid concentrations on sarcopenia are not well addressed yet. Objective The aim of this study was to compare the amino acid concentrations at each sta...

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Bibliographic Details
Published in:The Journal of nutrition, health & aging health & aging, 2018-07, Vol.22 (7), p.819-823
Main Authors: Yamada, Minoru, Kimura, Y., Ishiyama, D., Nishio, N., Tanaka, T., Ohji, S., Otobe, Y., Koyama, S., Sato, A., Suzuki, M., Ogawa, H., Ichikawa, T., Ito, D., Arai, H.
Format: Article
Language:English
Subjects:
Aged
Aging
Amino acids
Amino Acids, Branched-Chain - blood
Amino Acids, Essential - blood
Electric Impedance
Female
Geriatrics/Gerontology
Hand Strength - physiology
Humans
Independent Living
Japan
Longitudinal Studies
Medicine
Medicine & Public Health
Muscle function
Muscle Strength - physiology
Muscle, Skeletal - physiology
Neurosciences
Nutrition
Plasma
Primary Care Medicine
Quality of Life Research
Sarcopenia
Sarcopenia - physiopathology
Walking - physiology
Womens health
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Summary:Background Although several previous studies have found benefits for amino acid supplementation in terms of muscle function, the role of plasma amino acid concentrations on sarcopenia are not well addressed yet. Objective The aim of this study was to compare the amino acid concentrations at each stage of sarcopenia (normal, pre-sarcopenia, dynapenia, and sarcopenia) in community-dwelling older Japanese adults. Setting and Subjects: Community-dwelling older Japanese women (n=232, 79.4±7.0 years) participated in this study. Measurements We measured plasma amino acid concentrations, 5-m walking speed, grip strength, and skeletal muscle mass using a bioelectrical impedance data acquisition system and compared them among participants at each stage of sarcopenia. Results The proportions of normal, pre-sarcopenia, dynapenia, and sarcopenia patients were 40.5% (n=94), 12.1% (n=28), 26.3% (n=61), and 21.1% (n=49), respectively. Significant differences were observed for concentrations of leucine, branched-chain amino acid (BCAAs), and essential amino acid (EAAs) among the four groups (p
ISSN:1279-7707
1760-4788
DOI:10.1007/s12603-018-1014-8