Effect of parathyroid hormone on cellular immunity in uremic patients undergoing peritoneal dialysis

Objective The clinical relevance of altered lymphocyte function and its possible relation with uremic toxins such as parathyroid hormone (PTH) is not well understood. We studied the changes in cellular immunity in patients on continuous ambulatory peritoneal dialysis therapy and examined the relatio...

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Published in:Dialysis & transplantation 2006-10, Vol.35 (10), p.618-623
Main Authors: Griveas, I., Papadopoulou, D., Fleva, A., Visvardis, G., Pavlitou, A., Sakellariou, G.
Format: Article
Language:English
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Summary:Objective The clinical relevance of altered lymphocyte function and its possible relation with uremic toxins such as parathyroid hormone (PTH) is not well understood. We studied the changes in cellular immunity in patients on continuous ambulatory peritoneal dialysis therapy and examined the relationship between T‐lymphocyte function and plasma levels of PTH. Patients and Methods Thirty‐seven patients (16 male, 21 female) were enrolled in the study. The patients were divided into 2 groups: 22 patients with increased levels of PTH and 15 patients with normal levels of PTH. Lymphocyte subsets (CD2+, CD3+, CD3+/4+, CD3+/8+, CD19+, CD3−/16+56+, CD4/CD8 ratio) were quantitated in both groups using monoclonal antibodies and flow cytometric analysis. Analysis of variance testing was performed to analyze differences between the groups. Results A significant increase in CD3 was observed in patients with increased levels of PTH (71.6±7.9 vs. 57.5±28.1, p
ISSN:0090-2934
1932-6920
DOI:10.1002/dat.20054