Antiobesity Effects of Purple Perilla (Perilla frutescens var. acuta) on Adipocyte Differentiation and Mice Fed a High‐fat Diet

Purple perilla (PE) is a medicinal plant that has several health benefits. In this study, the antiobesity effect of PE was studied in 3T3‐L1 preadipocytes and C57BL/6J mice fed high‐fat diets. Triglyceride quantification and Oil Red O staining in matured adipocytes revealed that PE reduced lipid acc...

Full description

Saved in:
Bibliographic Details
Published in:Journal of food science 2018-09, Vol.83 (9), p.2384-2393
Main Authors: Thomas, Shalom Sara, Kim, Mina, Lee, Seung Je, Cha, Youn‐Soo
Format: Article
Language:English
Subjects:
3T3‐L1 preadipocytes
Adipocytes
Adipose tissue
Body weight
Body weight gain
C57BL/6J mice
Diet
Fatty acids
Functional foods & nutraceuticals
Gene expression
High fat diet
Lipids
Lipolysis
Liver
Medicinal plants
Mice
Obesity
Oils & fats
Oxidation
Polyphenols
Preadipocytes
purple perilla
Rodents
Rosmarinic acid
Serum lipids
Weight control
β‐oxidation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purple perilla (PE) is a medicinal plant that has several health benefits. In this study, the antiobesity effect of PE was studied in 3T3‐L1 preadipocytes and C57BL/6J mice fed high‐fat diets. Triglyceride quantification and Oil Red O staining in matured adipocytes revealed that PE reduced lipid accumulation in differentiated adipocytes by downregulating adipogenic gene and upregulating lipolytic gene expressions. Mice were fed normal diet, high‐fat diet and high‐fat diet supplemented with different concentrations of PE. Treatment with PE significantly prevented body weight gain, improved serum lipids, hepatic lipids and reduced the epididymal fat. Furthermore, in the adipose tissue and liver, expression of genes related to lipolysis and fatty acid β‐oxidation were upregulated in PE‐ treated mice. Thus, our results suggested that PE has antiobesity effects in rodents and can be effective in obesity management. Practical Application Purple perilla, rich in polyphenols such as rosmarinic acid, showed lipid lowering in adipocyte cells and prevented body weight gain in mice. Therefore we conclude that purple perilla may be a potential candidate for the development of functional foods or nutraceuticals in managing obesity in humans.
ISSN:0022-1147
1750-3841
DOI:10.1111/1750-3841.14288