Prognostic Significance of Neutrophil-to-lymphocyte Ratio in the Framework of the 8th TNM Edition for Breast Cancer

To investigate whether neutrophil-to-lymphocyte ratio (NLR) might represent an additional biological criterion able to identify patients with worse prognosis within the 8th edition TNM prognostic staging system for breast cancer (BC). Pre-treatment NLR was retrospectively analyzed in 475 BC women pr...

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Bibliographic Details
Published in:Anticancer research 2018-08, Vol.38 (8), p.4705-4712
Main Authors: Ferroni, Patrizia, Roselli, Mario, Buonomo, Oreste C, Spila, Antonella, Portarena, Ilaria, Laudisi, Anastasia, Valente, Maria G, Pirillo, Silvana P, Fortunato, Lucio, Costarelli, Leopoldo, Cavaliere, Francesco, Guadagni, Fiorella
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast cancer
Breast Neoplasms - pathology
Cancer
Disease-Free Survival
Female
Humans
Leukocyte Count - methods
Lymphocytes - pathology
Medical prognosis
Medical treatment
Metastases
Middle Aged
Neoplasm Recurrence, Local - pathology
Neoplasm Staging - methods
Neutrophils
Neutrophils - pathology
Patients
Prognosis
Prospective Studies
Retrospective Studies
Survival
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Summary:To investigate whether neutrophil-to-lymphocyte ratio (NLR) might represent an additional biological criterion able to identify patients with worse prognosis within the 8th edition TNM prognostic staging system for breast cancer (BC). Pre-treatment NLR was retrospectively analyzed in 475 BC women prospectively followed for a mean time of 3.8 years. The optimal NLR cutoff, identified by ROC analysis, was set at 2. Elevated pre-treatment NLR was associated with worse disease-free survival (DFS) (HR=2.28) and overall survival (OS) (HR=3.39). The prognostic value of NLR was mostly evident in stage I BC (HR for DFS=2.89; HR for OS=1.30), in whom NLR significantly stratified patients who developed distant metastasis (HR= 4.62), but not local recurrence. NLR might provide important information in risk stratification, especially in stage I BC patients in whom the presence of a high NLR might raise the question as to whether they should be more aggressively managed.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.12777