An investigation into the role of different constituents in damage accumulation in arterial tissue and constitutive model development

Carotid atherosclerotic plaque rupture is one of the leading causes of stroke. Treatments for atherosclerosis can induce tissue damage during the deployment of an intravascular device or through external tissue clamping during surgery. In this paper, a constituent specific study was performed to inv...

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Bibliographic Details
Published in:Biomechanics and modeling in mechanobiology 2018-12, Vol.17 (6), p.1757-1769
Main Authors: Ghasemi, Milad, Nolan, David R., Lally, Caitríona
Format: Article
Language:English
Subjects:
Algorithms
Animals
Aorta
Arteries
Arteries - physiology
Arteriosclerosis
Atherosclerosis
Bioaccumulation
Biological and Medical Physics
Biomechanical Phenomena
Biomedical Engineering and Bioengineering
Biophysics
Calibration
Carotid arteries
Carotid Arteries - pathology
Carotid artery
Carotid Artery Diseases - physiopathology
Collagen
Collagen - chemistry
Collagenase
Collagenases - chemistry
Constituents
Constitutive models
Continuum damage mechanics
Cyclic loads
Damage accumulation
Deformation
Deformation mechanisms
Elasticity
Engineering
Fibers
Finite Element Analysis
Materials Testing
Mathematical models
Mechanical tests
Models, Cardiovascular
Original Paper
Physiology
Rupture
Space life sciences
Stress, Mechanical
Stress, Physiological
Surgery
Swine
Tensile Strength
Theoretical and Applied Mechanics
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Summary:Carotid atherosclerotic plaque rupture is one of the leading causes of stroke. Treatments for atherosclerosis can induce tissue damage during the deployment of an intravascular device or through external tissue clamping during surgery. In this paper, a constituent specific study was performed to investigate the role of the ground matrix and collagen fibres of arterial tissue in response to supra-physiological loads. Cyclic mechanical tests were conducted on intact and collagenase-digested strips of porcine common carotid arteries. Using these tests, four passive damage-relevant phenomena were studied, namely (i) Mullins effect, (ii) hysteresis, (iii) permanent set and (iv) matrix failure and fibre rupture. A constitutive model was also developed to capture all of these damage-relevant phenomena using a continuum damage mechanics approach. The implemented constitutive model was fit to experimental results for both intact and digested samples. The results of this work demonstrate the important role of the ground matrix in the permanent deformation of the arterial tissue under high loads. Supra-physiological load-induced tissue damage may play a key role in vascular remodelling in arteries with atherosclerosis or following interventional procedures.
ISSN:1617-7959
1617-7940
DOI:10.1007/s10237-018-1054-3