Comparison of the tissue response of selective retina therapy with or without real-time feedback-controlled dosimetry

Purpose The purpose of this study is to evaluate the retinal tissue response upon selective retina therapy (SRT) with or without real-time feedback-controlled dosimetry (RFD) in rabbits. Methods Eighteen eyes of nine Chinchilla Bastard rabbits were treated by SRT with or without RFD (Q-switched Nd:Y...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2018-09, Vol.256 (9), p.1639-1651
Main Authors: Minhee, Kim, Park, Young-Gun, Kang, Seungbum, Roh, Young Jung
Format: Article
Language:English
Subjects:
Animals
Basic Science
Disease Models, Animal
Dosimetry
Energy
Epithelium
Feedback
Fluorescein Angiography - methods
Fundus Oculi
Laser Coagulation - methods
Lasers, Solid-State - therapeutic use
Medicine
Medicine & Public Health
Ophthalmology
Ophthalmoscopy
Rabbits
Retina
Retinal Diseases - diagnosis
Retinal Diseases - therapy
Retinal pigment epithelium
Retinal Pigment Epithelium - pathology
Scanning electron microscopy
Tomography, Optical Coherence - methods
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Summary:Purpose The purpose of this study is to evaluate the retinal tissue response upon selective retina therapy (SRT) with or without real-time feedback-controlled dosimetry (RFD) in rabbits. Methods Eighteen eyes of nine Chinchilla Bastard rabbits were treated by SRT with or without RFD (Q-switched Nd:YLF, wavelength 527 nm, pulse duration 1.7 μs). RFD operated by optoacoustic and reflectometric methods detects the microbubbles from retinal pigment epithelium (RPE) damage in real time. After SRT, light microscopy (LM) and scanning electron microscopy (SEM) were performed at 1 h, 1 day, 3 days, 7 days, and 1 month. The RPE-damaged area on SEM was measured by ImageJ 1 h after SRT. Results Without RFD, the RPE-damaged area of 76 SRT-treated spots showed a strong positive correlation with ramping pulse energy (Pearson’s correlation coefficient, 0.706; P  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-018-4067-9