Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation

Neutrophils may be an important source of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), two matrix-degrading enzymes thought to be critical in the formation of an abdominal aortic aneurysm (AAA). The purpose of this investigation was to test the hypothesis that neutrophi...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2005-07, Vol.112 (2), p.232-240
Main Authors: ELIASON, Jonathan L, HANNAWA, Kevin K, STANLEY, James C, THOMPSON, Robert W, UPCHURCH, Gilbert R, AILAWADI, Gorav, SINHA, Indranil, FORD, John W, DEOGRACIAS, Michael P, ROELOFS, Karen J, WOODRUM, Derek T, ENNIS, Terri L, HENKE, Peter K
Format: Article
Language:English
Subjects:
Animals
Antibodies, Antineutrophil Cytoplasmic - administration & dosage
Antibodies, Antineutrophil Cytoplasmic - pharmacology
Aortic Aneurysm, Abdominal - etiology
Aortic Aneurysm, Abdominal - prevention & control
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular system
Diseases of the aorta
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Investigative techniques, diagnostic techniques (general aspects)
Lymphocyte Depletion
Matrix Metalloproteinase 2 - genetics
Matrix Metalloproteinase 8 - analysis
Matrix Metalloproteinase 9 - genetics
Medical sciences
Mice
Mice, Inbred C57BL
Neutropenia - chemically induced
Neutrophils - enzymology
Pancreatic Elastase - administration & dosage
Radiodiagnosis. Nmr imagery. Nmr spectrometry
RNA, Messenger - analysis
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Summary:Neutrophils may be an important source of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), two matrix-degrading enzymes thought to be critical in the formation of an abdominal aortic aneurysm (AAA). The purpose of this investigation was to test the hypothesis that neutrophil depletion would limit experimental AAA formation by altering one or both of these enzymes. Control, rabbit serum-treated (RS; n=27) or anti-neutrophil-antibody-treated (anti-PMN; n=25) C57BL/6 mice underwent aortic elastase perfusion to induce experimental aneurysms. Anti-PMN-treated mice became neutropenic (mean, 349 cells/microL), experiencing an 84% decrease in the circulating absolute neutrophil count (P
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.104.517391