Azoles and antidepressants: a mini-review of the tolerability of co-administration

Depression is a common condition in chronically ill immunosuppressed patients on long-term antifungal therapy with azoles. As both azoles and more recent antifungals are metabolised by the P450 enzymatic system in the liver, here we review the potential of clinically meaningful interactions between...

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Bibliographic Details
Published in:Mycoses 2009-09, Vol.52 (5), p.433-439
Main Authors: Roussos, P, Lewis, R.E, Kontoyiannis, D.P
Format: Article
Language:eng ; ger
Subjects:
antidepressants
Antidepressive Agents - therapeutic use
Antifungal Agents - therapeutic use
antifungal therapy
Azoles
Azoles - therapeutic use
depression
Drug Interactions
Humans
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Summary:Depression is a common condition in chronically ill immunosuppressed patients on long-term antifungal therapy with azoles. As both azoles and more recent antifungals are metabolised by the P450 enzymatic system in the liver, here we review the potential of clinically meaningful interactions between antidepressants and azoles. Selective serotonin reuptake inhibitors are safer compared to tricycle antidepressants when co-administered with azoles. More pharmacovigilance is needed.
ISSN:0933-7407
1439-0507
DOI:10.1111/j.1439-0507.2008.01677.x