Identification of regulatory mechanisms of the hepatic response to thermal injury

The purpose of this paper is to evaluate the hypothesis that a systems biology approach can be developed such that a set of transcription factors, relevant to burn-induced inflammatory response can be identified and modulated to control the host response. We explore a novel method for identifying co...

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Bibliographic Details
Published in:Computers & chemical engineering 2008, Vol.32 (1), p.356-369
Main Authors: Yang, E., Maguire, T.J., Yarmush, M.L., Berthiaume, F., Androulakis, I.P.
Format: Article
Language:English
Subjects:
Burn
Gene expression
Inflammation
Transcritpion factors
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Summary:The purpose of this paper is to evaluate the hypothesis that a systems biology approach can be developed such that a set of transcription factors, relevant to burn-induced inflammatory response can be identified and modulated to control the host response. We explore a novel method for identifying coherent and informative expression motifs and we subsequently determine conserved transcription factor binding sites for the sub-sets of co-expressed genes. The responses are rationalized in the context of burn-induced inflammation and the putative transcription factors are rationalized in the context of intervention targets for controlling gene expression.
ISSN:0098-1354
1873-4375
DOI:10.1016/j.compchemeng.2007.02.009