Altered pulmonary function in children with asthma associated with highway traffic near residence

Cross-sectional analyses were conducted to evaluate the effects of exposure to highway traffic on pulmonary function in Fresno, California. Traffic and spirometry data were available for 214 children (enrollment ages six to 11 years). Multiple linear regression was used to evaluate the relations bet...

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Bibliographic Details
Published in:International journal of environmental health research 2009-04, Vol.19 (2), p.139-155
Main Authors: Margolis, Helene G., Mann, Jennifer K., Lurmann, Frederick W., Mortimer, Kathleen M., Balmes, John R., Hammond, S. Katharine, Tager, Ira B.
Format: Article
Language:English
Subjects:
air pollution
asthma
Asthma - physiopathology
Child
children
Cross-Sectional Studies
Environmental Exposure
Female
Humans
Lung - physiopathology
Male
pulmonary function
Regression Analysis
Residence Characteristics
Respiratory Function Tests
traffic
Vehicle Emissions - toxicity
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Summary:Cross-sectional analyses were conducted to evaluate the effects of exposure to highway traffic on pulmonary function in Fresno, California. Traffic and spirometry data were available for 214 children (enrollment ages six to 11 years). Multiple linear regression was used to evaluate the relations between pulmonary function and traffic parameters. Heavy-duty vehicle count was used as a surrogate measure for diesel-related exposures. Pulmonary function was non-significantly associated with longer distance-to-road and non-significantly associated with higher traffic intensity. Evaluation of effect modification by FEF 25-75 /FVC (a measure of intrinsic airway size) showed that all pulmonary function measures of flow were significantly inversely related to a traffic metric that incorporates traffic intensity and roadway proximity. The results indicate that residence proximity to highway traffic is associated with lower pulmonary function among children with asthma, and smaller airway size is an important modifier of the effect of traffic exposure on pulmonary function and a marker of increased susceptibility.
ISSN:0960-3123
1369-1619
DOI:10.1080/09603120802415792