TFF1 antagonizes TIMP‐1 mediated proliferative functions in gastric cancer

Tissue inhibitor matrix metalloproteinase‐1 (TIMP1) is one of four identified members of the TIMP family. We evaluated the role of TIMP1 in gastric cancer using human and mouse tissues along with gastric organoids and in vitro cell models. Using quantitative real‐time RT‐PCR, we detected significant...

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Bibliographic Details
Published in:Molecular carcinogenesis 2018-11, Vol.57 (11), p.1577-1587
Main Authors: Omar, Omar M., Soutto, Mohammed, Bhat, Nadeem S., Bhat, Ajaz A., Lu, Heng, Chen, Zheng, El‐Rifai, Wael
Format: Article
Language:English
Subjects:
Animal models
Animals
Cell culture
Cell Culture Techniques
Cell Line, Tumor
Cell Proliferation
Disease Models, Animal
Gastric cancer
Gene expression
Gene Expression Regulation, Neoplastic
Gene Silencing
Humans
Immunofluorescence
Inhibition
Lesions
Localization
Matrix metalloproteinase
Metalloproteinase
Mice
Mice, Knockout
Models, Biological
NF-kappa B
NFκB
Organoids
Stomach
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
TFF1
TIMP1
Tissue inhibitor of metalloproteinase 1
Tissue Inhibitor of Metalloproteinase-1 - genetics
Tissue Inhibitor of Metalloproteinase-1 - metabolism
Tissues
Trefoil Factor-1 - metabolism
Tumor cell lines
Tumor necrosis factor
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Summary:Tissue inhibitor matrix metalloproteinase‐1 (TIMP1) is one of four identified members of the TIMP family. We evaluated the role of TIMP1 in gastric cancer using human and mouse tissues along with gastric organoids and in vitro cell models. Using quantitative real‐time RT‐PCR, we detected significant overexpression of TIMP1 in the human gastric cancer samples, as compared to normal stomach samples (P 
ISSN:0899-1987
1098-2744
DOI:10.1002/mc.22880