Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats

Leukotriene inhibiting boswellic acids and glucosamine individually are known for their anti-arthritic potential in preclinical and clinical studies. A combination of both displayed significant synergism in chronic inflammation, whereas in acute inflammation it was almost insignificant. The present...

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Published in:Bioorganic & medicinal chemistry letters 2007-07, Vol.17 (13), p.3706-3711
Main Authors: Singh, Surjeet, Khajuria, Anamika, Taneja, Subhash Chandra, Khajuria, Ravi Kant, Singh, Jaswant, Qazi, Ghulam Nabi
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Arthritis - drug therapy
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Carrageenan - pharmacology
Chemistry, Pharmaceutical - methods
Drug Design
Drug Evaluation, Preclinical
Drug Synergism
Edema
Glucosamine - chemistry
Glucosamine - metabolism
Magnetic Resonance Spectroscopy
Medical sciences
Models, Chemical
Mycobacterium - metabolism
Pharmacology. Drug treatments
Rats
Triterpenes - chemistry
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Summary:Leukotriene inhibiting boswellic acids and glucosamine individually are known for their anti-arthritic potential in preclinical and clinical studies. A combination of both displayed significant synergism in chronic inflammation, whereas in acute inflammation it was almost insignificant. The present study revealed the synergistic effect of boswellic acid mixture (BA) and glucosamine for anti-inflammatory and anti-arthritic activities in rats. Two studies were conducted, that is, acute anti-inflammatory by carrageenan edema and chronic anti-arthritic by Mycobacterium-induced developing arthritis. Five groups of animals were included in each of the study: the vehicle control, positive control (ibuprofen 100 mg/kg), boswellic acids (250 mg/kg), glucosamine (250 mg/kg) and a combination of boswellic acids (125 mg/kg) and glucosamine (125 mg/kg). BA when administered at 250 mg/kg in rats, carrageenan-induced paw edema and Mycobacterium-induced developing arthritis were significantly inhibited. In comparison to boswellic acids, glucosamine when administered at 250 mg/kg showed a mild effect in carrageenan-induced edema and moderate inhibition of paw swelling against developing arthritis. Although the combination of boswellic acids and glucosamine did not affect the acute inflammation to a greater extent yet a significant anti-arthritic activity was observed in rats. In conclusion, a synergistic effect was observed in chronic inflammatory conditions when two chemical entities were administered in combination in preclinical study.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2007.04.034