Cardiac amyloidosis imaging with amyloid positron emission tomography: A systematic review and meta-analysis

Recent progress in amyloid positron emission tomography (PET) has enabled the targeted imaging of cardiac amyloidosis with accuracy. We performed a systematic review and meta-analysis on the diagnostic performance of cardiac amyloidosis using amyloid PET. A systematic search was performed using key...

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Bibliographic Details
Published in:	Journal of nuclear cardiology 2020-02, Vol.27 (1), p.123-132
Main Authors:	Kim, Yong Joong, Ha, Sejin, Kim, Yong-il
Format:	Article
Language:	eng
Subjects:	Amyloid Amyloid Neuropathies, Familial - diagnostic imaging Amyloidosis Cardiology diagnosis heart Heart Diseases - diagnostic imaging Humans Imaging Medical diagnosis Medical imaging Medicine Medicine & Public Health Nuclear Medicine Original Article Positron-Emission Tomography Radiology Sensitivity and Specificity Systematic review Tomography
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Summary:	Recent progress in amyloid positron emission tomography (PET) has enabled the targeted imaging of cardiac amyloidosis with accuracy. We performed a systematic review and meta-analysis on the diagnostic performance of cardiac amyloidosis using amyloid PET. A systematic search was performed using key words: cardiac amyloidosis, amyloid, and PET. We estimated the pooled sensitivity, specificity, positive and negative likelihood ratio (LR), and diagnostic odds ratio (DOR). Furthermore, the semiquantitative parameters of PET were evaluated to diagnose cardiac amyloidosis and discern its type [systemic light chain amyloidosis (AL) vs transthyretin amyloidosis (ATTR)] using the pooled standardized mean difference (SMD). In total, six eligible studies with a total of 98 subjects were included in this meta-analysis. The pooled sensitivity was 0.95, the specificity was 0.98, positive LR was 10.130, negative LR was 0.1, and DOR was 148.83. The semiquantitative parameters of amyloid PET showed significantly higher values for cardiac amyloidosis patients than those for controls (pooled SMD = 1.42; P < .001), and in AL than ATTR (pooled SMD = 0.96; P < .001). Amyloid PET imaging can be a useful method for diagnosing cardiac amyloidosis. The semiquantitative parameters of amyloid PET can help diagnose cardiac amyloidosis and discern its type.
ISSN:	1071-3581 1532-6551