Association between dietary total antioxidant capacity and hepatocellular ballooning in nonalcoholic steatohepatitis: a cross-sectional study

Purpose Nonalcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation, ballooning, and in some cases, fibrosis, which can progress to cirrhosis and carcinoma. The progression of NASH is closely related to oxidative stress. Dietary intake of antioxidants has been suggested i...

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Bibliographic Details
Published in:European journal of nutrition 2019-09, Vol.58 (6), p.2263-2270
Main Authors: de Oliveira, Daiane Gonçalves, de Faria Ghetti, Fabiana, Moreira, Ana Paula Boroni, Hermsdorff, Helen Hermana Miranda, de Oliveira, Juliano Machado, de Castro Ferreira, Lincoln Eduardo Villela Vieira
Format: Article
Language:English
Subjects:
Anthropometry
Antioxidants
Antioxidants - administration & dosage
Antioxidants - pharmacology
Balloon treatment
Biopsy
Body composition
Chemistry
Chemistry and Materials Science
Cirrhosis
Cross-Sectional Studies
Diet
Diet - methods
Dietary intake
Female
Fibrosis
Food intake
Hepatocytes
Hepatocytes - drug effects
Hepatocytes - pathology
Humans
Liver
Liver - pathology
Liver cirrhosis
Liver diseases
Male
Middle Aged
Non-alcoholic Fatty Liver Disease - diet therapy
Non-alcoholic Fatty Liver Disease - pathology
Nutrition
Original Contribution
Oxidative stress
Oxidative Stress - drug effects
Severity of Illness Index
Steatosis
Surveys and Questionnaires
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Summary:Purpose Nonalcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation, ballooning, and in some cases, fibrosis, which can progress to cirrhosis and carcinoma. The progression of NASH is closely related to oxidative stress. Dietary intake of antioxidants has been suggested in protection against oxidative damage and related clinical complications. Thus, we evaluated the potential association of dietary total antioxidant capacity (TAC) with disease severity in NASH patients, as well as with anthropometric and body composition markers and biochemical parameters. Methods Thirty-three outpatients with a mean age of 48.4 ± 1.9 years were evaluated. Dietary TAC was estimated from a quantitative food frequency questionnaire. NASH severity, determined by liver biopsy, lifestyle characteristics, occurrence of comorbidities, anthropometry, body composition, and biochemical parameters were assessed. Results NASH patients who had a higher dietary TAC had fewer ballooned hepatocytes compared to those with a lower TAC ( p  = 0.024). The patients with the highest dietary TAC had a reduction of approximately 20% in the risk of having many ballooned hepatocytes (OR 0.791; 95% CI 0.643–0.974; p  = 0.027). There was no association of steatosis, lobular inflammation, and fibrosis with dietary TAC. The same occurred for lifestyle characteristics, occurrence of comorbidities, anthropometry, body composition, and biochemical parameters. Conclusion Dietary TAC is higher in patients with lower hepatic injury (ballooning), suggesting a possible role of food intake naturally high in its antioxidant capacity in reducing free radical production and, consequently, oxidative stress.
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-018-1776-0