Prospective comparison of diffusion-weighted MRI and dynamic Gd-EOB-DTPA-enhanced MRI for detection and staging of hepatic fibrosis in primary sclerosing cholangitis

Purpose To assess the diagnostic value of multiparametric magnetic resonance imaging (MRI) including dynamic Gd-EOB-DTPA-enhanced (DCE) and diffusion-weighted (DW) imaging for diagnosis and staging of hepatic fibrosis in primary sclerosing cholangitis (PSC) using transient elastography as a standard...

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Bibliographic Details
Published in:European radiology 2019-02, Vol.29 (2), p.818-828
Main Authors: Keller, S., Sedlacik, J., Schuler, T., Buchert, R., Avanesov, M., Zenouzi, R., Lohse, A. W., Kooijman, H., Fiehler, J., Schramm, C., Yamamura, J.
Format: Article
Language:English
Subjects:
Adult
Blood flow
Cholangitis
Cholangitis, Sclerosing - complications
Cholangitis, Sclerosing - diagnostic imaging
Cirrhosis
Contrast Media
Correlation analysis
Cross-Sectional Studies
Diagnostic Radiology
Diagnostic systems
Diffusion
Diffusion coefficient
Diffusion Magnetic Resonance Imaging - methods
Elasticity Imaging Techniques - methods
Female
Fibrosis
Gadolinium
Gadolinium DTPA
Humans
Imaging
Internal Medicine
Interventional Radiology
Liver
Liver cirrhosis
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - etiology
Liver diseases
Magnetic Resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Mathematical analysis
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
NMR
Nuclear magnetic resonance
Observer Variation
Parameters
Patients
Portal Vein - diagnostic imaging
Prospective Studies
Radiology
ROC Curve
Sensitivity and Specificity
Severity of Illness Index
Spleen
Spleen - diagnostic imaging
Spleen - pathology
Stiffness
Transit time
Ultrasound
Variance analysis
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Summary:Purpose To assess the diagnostic value of multiparametric magnetic resonance imaging (MRI) including dynamic Gd-EOB-DTPA-enhanced (DCE) and diffusion-weighted (DW) imaging for diagnosis and staging of hepatic fibrosis in primary sclerosing cholangitis (PSC) using transient elastography as a standard reference. Material and methods Multiparametric MRI was prospectively performed on a 3.0-Tesla scanner in 47 patients (age 43.9±14.3 years). Transient elastography derived liver stiffness measurements (LSM), DCE-MRI derived parameters (hepatocellular uptake rate (Ki), arterial (Fa), portal venous (Fv) and total (Ft) blood flow, mean transit time (MTT), and extracellular volume (Ve)) and the apparent diffusion coefficient (ADC) were calculated. Correlation and univariate analysis of variance with post hoc pairwise comparison were applied to test for differences between LSM derived fibrosis stages (F0/F1, F2/3, F4). ROC curve analysis was used as a performance measure. Results Both ADC and Ki correlated significantly with LSM (r= -0.614; p
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-018-5614-9