Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from Ervatamia divaricata

Ervadivamines A (1) and B (2), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from Ervatamia divaricata. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C–C and C–N linkage patterns. Their structures including absolute configurations were full...

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Bibliographic Details
Published in:Journal of organic chemistry 2018-09, Vol.83 (17), p.10613-10618
Main Authors: Liu, Zhi-Wen, Zhang, Jian, Li, Song-Tao, Liu, Ming-Qun, Huang, Xiao-Jun, Ao, Yun-Lin, Fan, Chun-Lin, Zhang, Dong-Mei, Zhang, Qing-Wen, Ye, Wen-Cai, Zhang, Xiao-Qi
Format: Article
Language:English
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Summary:Ervadivamines A (1) and B (2), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from Ervatamia divaricata. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C–C and C–N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In addition, compound 1 exhibited significant cytotoxicity against four cancer cells.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.8b01371