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Sero-prevalence of leptospirosis and differentiation in blood parameters between positive and negative cases in dogs of Kathmandu Valley

Leptospirosis is a zoonotic disease with worldwide distribution. It affects both humans and animals. Dogs may serve as a sentinel as well as a potential carrier for Leptospira infection in human. This study was conducted with the aim of investigating the sero-prevalence of leptospirosis, and differe...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2018-08, Vol.112 (8), p.378-382
Main Authors: Ojha, Krishna Chandra, Singh, Dinesh Kumar, Kaphle, Krishna, Shah, Yogendra, Pant, Dhan Kumar
Format: Article
Language:English
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Summary:Leptospirosis is a zoonotic disease with worldwide distribution. It affects both humans and animals. Dogs may serve as a sentinel as well as a potential carrier for Leptospira infection in human. This study was conducted with the aim of investigating the sero-prevalence of leptospirosis, and differentiation in blood parameters in positive and negative cases of dogs. A cross-sectional study was carried out from August 2016 to December 2016 in Kathmandu valley. A total of 70 blood samples were collected from street dogs and tested against Leptospira infection using Immunocomb Canine Leptospira Antibody Test Kit. Out of 70 blood samples tested, eight samples (11.4%) were positive. The average mean and SD of total leucocyte count of positive and negative cases were 79 750±12 090/mm3 and 11 026.98±4316.742/mm3, respectively. Levels of blood parameters (total leukocyte count (TLC), blood glucose, serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), and calcium and phosphorus) were found to be increased, and significant between positive and negative cases p
ISSN:0035-9203
1878-3503
DOI:10.1093/trstmh/try065