Delayed orthostatic hypotension: Severity of clinical symptoms and response to medical treatment

Severity of orthostatic intolerance and the benefit of medical treatment in patients with delayed OH have not been elucidated. This study aimed to compare the symptom severity between classic and delayed OH and evaluate the efficacy of midodrine or pyridostigmine in patients with delayed OH. This wa...

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Bibliographic Details
Published in:Autonomic neuroscience 2018-09, Vol.213, p.81-85
Main Authors: Byun, Jung-Ick, Moon, Jangsup, Kim, Do-Yong, Shin, Hyerim, Sunwoo, Jun-Sang, Lim, Jung-Ah, Kim, Tae-Joon, Lee, Woo-Jin, Lee, Han Sang, Jun, Jin-Sun, Park, Kyung-Il, Lee, Soon-Tae, Jung, Keun-Hwa, Jung, Ki-Young, Kim, Manho, Lee, Sang Kun, Chu, Kon
Format: Article
Language:English
Subjects:
Delayed orthostatic hypotension
Efficacy
Midodrine
Pyridostigmine
Treatment
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Summary:Severity of orthostatic intolerance and the benefit of medical treatment in patients with delayed OH have not been elucidated. This study aimed to compare the symptom severity between classic and delayed OH and evaluate the efficacy of midodrine or pyridostigmine in patients with delayed OH. This was an adjunctive study of previously reported randomized, open-label clinical trials evaluating the efficacy and safety of midodrine or pyridostigmine for classic OH. Seventeen patients with delayed OH were enrolled and also received midodrine (2.5 mg twice a day) or pyridostigmine (30 mg twice a day) alone or combined. Result of initial orthostatic vital sign and questionnaires were compared between the patients with delayed OH and previously reported 87 patients with classic OH. Delayed OH patients were followed up at 1 and 3 months post-treatment and the vital sign measurements and questionnaires were repeated during the follow-up period. Questionnaire scores regarding OH-related symptoms, depression and health-related quality of life (HRQOL) were comparable between the classic and delayed OH patients at baseline. OH-related symptoms and depression were significantly improved after 3 months of medical treatment. Patients with delayed OH exhibited orthostatic intolerance similar to that of classic OH. This study shows that these patients may benefit from medical treatment with either midodrine or pyridostigmine. •Patients with delayed OH had less severe orthostatic BP drop than the classic OH.•Patients with delayed OH exhibited orthostatic intolerance similar to that of classic OH.•Medical treatment improved standing BP drop and associated symptoms in patients with delayed OH.
ISSN:1566-0702
1872-7484
DOI:10.1016/j.autneu.2018.06.005