MORPHOLOGICAL CHARACTERISTICS OF SPONTANEOUS AND 239-PLUTONIUM-INDUCED LUNG TUMORS IN THE CBA MOUSE

Groups of female CBA/Ca mice were sham-exposed, or exposed to 239PuO2 by single dose inhalation to give a mean initial alveolar deposit of 95.6 Bq. Subgroups of control and plutonium-exposed mice were killed at 4-mo intervals from 8 mo until 28 mo. After this time, surviving mice were maintained for...

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Published in:Inhalation toxicology 1998, Vol.10 (4), p.321-356
Main Authors: Brooks, Paul N, Kellington, Jeremy P
Format: Article
Language:English
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Summary:Groups of female CBA/Ca mice were sham-exposed, or exposed to 239PuO2 by single dose inhalation to give a mean initial alveolar deposit of 95.6 Bq. Subgroups of control and plutonium-exposed mice were killed at 4-mo intervals from 8 mo until 28 mo. After this time, surviving mice were maintained for the remainder of their life span or killed when moribund. The lungs of all animals were examined, and putative neoplasms identified and excised for histopathological evaluation. Each lung tumor was evaluated histopathologically for cellular composition, growth pattern, behavior, and size, and correlations were made between the incidences of alveolar adenoma or carcinoma and the various morphological characteristics. Alveolar-cell neoplasia was the only lung tumor type to be identified in this investigation. There were no qualitative differences between 239PuO2-induced lung tumors and those arising spontaneously in sham-exposed mice. In general, the data revealed considerable morphological heterogeneity both between and within individual tumors.
ISSN:0895-8378
1091-7691
DOI:10.1080/089583798197709