Increased risk of incident psoriasis in end‐stage renal disease patients on chronic hemodialysis: A nationwide population‐based cohort study

Patients with end‐stage renal disease (ESRD) on chronic hemodialysis (HD) experience chronic inflammation and immune dysregulation; whether these affect the development of chronic inflammatory disease such as psoriasis is unknown. We aimed to investigate the impact of ESRD on the development of psor...

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Bibliographic Details
Published in:Journal of dermatology 2018-09, Vol.45 (9), p.1063-1070
Main Authors: Wang, Chia‐Chen, Tang, Chao‐Hsiun, Huang, Kuan‐Chih, Huang, Siao‐Yuan, Sue, Yuh‐Mou
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Arthritis
Cohort analysis
end‐stage renal disease
Epidemiology
Female
Health risk assessment
Hemodialysis
Humans
Incidence
inflammation
Kidney diseases
Kidney Failure, Chronic - immunology
Kidney Failure, Chronic - therapy
Male
Middle Aged
Population studies
Population-based studies
Psoriasis
Psoriasis - epidemiology
Psoriasis - immunology
Psoriatic arthritis
Renal Dialysis
Retrospective Studies
Risk Assessment
Risk Factors
Taiwan - epidemiology
Young Adult
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Summary:Patients with end‐stage renal disease (ESRD) on chronic hemodialysis (HD) experience chronic inflammation and immune dysregulation; whether these affect the development of chronic inflammatory disease such as psoriasis is unknown. We aimed to investigate the impact of ESRD on the development of psoriasis. We performed a retrospective cohort study using records between 1999 and 2013 from Taiwan's National Health Insurance Research Database. Among 74 916 patients with ESRD on chronic HD and the control group comprising 74 916 sex and age group‐matched patients, 165 and 81 incident psoriasis developed after a mean follow up of 2.4 and 2.9 years, respectively. The incidence rates of psoriasis in HD patients and the control group were 91.7 and 37.1 per 100 000 person‐years, respectively (difference between groups, P < 0.001). HD patients had a shorter time to psoriasis diagnosis than the control group (P < 0.05). Cox proportional hazard adjustment showed the hazard ratio (HR) for psoriasis in HD patients as 2.09 (95% confidence interval [CI], 1.49–2.94; P < 0.001) than that of the control group. Younger HD patients had relatively higher risk of psoriatic development (age
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.14531