Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration

A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl2 and BP nanosheets (BPs) into poly(lactic-co-glycolic acid) (PLGA) for bone regeneration. The fabricated BP-SrCl2/PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. Th...

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Bibliographic Details
Published in:Biomaterials 2018-10, Vol.179, p.164-174
Main Authors: Wang, Xuzhu, Shao, Jundong, Abd El Raouf, Mustafa, Xie, Hanhan, Huang, Hao, Wang, Huaiyu, Chu, Paul K., Yu, Xue-Feng, Yang, Yang, AbdEl-Aal, AbdelBasit M., Mekkawy, Nefissa H.M., Miron, Richard J., Zhang, Yufeng
Format: Article
Language:English
Subjects:
2D materials
Black phosphorus
Bone regeneration
Near-infrared
Photothermal effect
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Summary:A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl2 and BP nanosheets (BPs) into poly(lactic-co-glycolic acid) (PLGA) for bone regeneration. The fabricated BP-SrCl2/PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr2+ by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability. Implantation of the BP-SrCl2/PLGA microspheres into a rat femoral defect demonstrates good tissue compatibility and excellent bone regeneration capacity under NIR light irradiation. Our study indicates that local release of Sr2+ at optimal time periods controlled by NIR irradiation improves bone regeneration significantly and this NIR-triggered drug delivery system composed of BPs is suitable for therapies requiring precise control at specific time. [Display omitted]
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2018.06.039