Determination of the Phenoxyacid Herbicides MCPA, Mecoprop and 2,4-D in Kidney Tissue Using Liquid Chromatography with Electrospray Tandem Mass Spectrometry

An analytical method was developed to determine the phenoxyacid herbicides 2,4-D, MCPA and mecoprop in kidney tissue from animals where poisoning is suspected. Samples were Soxhlet extracted using diethyl ether and the extracts cleaned-up using anion exchange solid phase extraction cartridges. Analy...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 2009-06, Vol.82 (6), p.711-715
Main Authors: Charlton, Andrew J. A, Stuckey, Vicki, Sykes, Mark D
Format: Article
Language:English
Subjects:
2,4-Dichlorophenoxyacetic Acid - analysis
2,4-Dichlorophenoxyacetic Acid - isolation & purification
2,4-Dichlorophenoxyacetic Acid - poisoning
2-Methyl-4-chlorophenoxyacetic Acid - analogs & derivatives
2-Methyl-4-chlorophenoxyacetic Acid - analysis
2-Methyl-4-chlorophenoxyacetic Acid - isolation & purification
2-Methyl-4-chlorophenoxyacetic Acid - poisoning
Animals
Aquatic Pollution
Chromatography
Chromatography, Liquid - methods
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Herbicides
Kidney - chemistry
Kidneys
Poisoning
Pollution
Soil Science & Conservation
Solid Phase Extraction - methods
Spectrometry, Mass, Electrospray Ionization - methods
Swine
Tandem Mass Spectrometry
Toxicology
Waste Water Technology
Water Management
Water Pollution Control
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Summary:An analytical method was developed to determine the phenoxyacid herbicides 2,4-D, MCPA and mecoprop in kidney tissue from animals where poisoning is suspected. Samples were Soxhlet extracted using diethyl ether and the extracts cleaned-up using anion exchange solid phase extraction cartridges. Analysis was performed using liquid chromatography with negative-ion electrospray tandem mass spectrometry (LC-MS/MS). The method was evaluated by analysing control kidney samples fortified at 1 and 5 mg/kg. Mean recoveries ranged from 82 to 93% with relative standard deviations from 3.2 to 19%. The limit of detection was estimated to be 0.02 mg/kg.
ISSN:0007-4861
1432-0800
DOI:10.1007/s00128-009-9636-5