Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway

This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (cont...

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Bibliographic Details
Published in:Neuromolecular medicine 2018-09, Vol.20 (3), p.386-400
Main Authors: Belviranlı, Muaz, Okudan, Nilsel
Format: Article
Language:English
Subjects:
Accessory Atrioventricular Bundle
Aging
Aging - metabolism
Animals
Anxiety
Anxiety - etiology
Anxiety - therapy
Biomedical and Life Sciences
Biomedicine
Body Weight - physiology
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - biosynthesis
Brain-Derived Neurotrophic Factor - metabolism
Cognitive ability
Cognitive Dysfunction - metabolism
Cognitive Dysfunction - prevention & control
Exploratory Behavior - physiology
Female
Fibronectins - biosynthesis
Fibronectins - metabolism
Fitness training programs
Forkhead protein
Hippocampus
Hippocampus - metabolism
Internal Medicine
Locomotion - physiology
Locomotor activity
Neurology
Neurosciences
NF-κB protein
Original Paper
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - biosynthesis
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism
Physical Conditioning, Animal - physiology
Protein expression
Rats
Rodents
Signal Transduction
Spatial memory
Spatial Memory - physiology
TOR protein
Transcription activation
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Summary:This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (control vs. exercise training). The rats that exercised voluntarily performed exercise training for 90 days, and then all the rats underwent several methods of behavioral assessment. Locomotor activity and spatial memory were lower but anxiety scores were higher in the aged control rats, than in the young control, young exercised, and aged exercised rats ( P  
ISSN:1535-1084
1559-1174
DOI:10.1007/s12017-018-8500-3