Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case

Visceral leishmaniasis is a systemic disease that is potentially severe and endemic in Brazil. It clinically manifests as fever, weight loss, swelling, hepatosplenomegaly, paleness, and edema. In this study, we discuss a case of a 1-year-old child diagnosed with refractory visceral leishmaniasis aft...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2018, Vol.51 (3), p.393-396
Main Authors: Gomes, Maria Antonia Ferreira, Medeiros, Lana Lira Cantidio de, Lobo, Fernanda Paula Dantas, Wanderley, Nathália Rayane Silva, Matos, Ana Paula Rodrigues, Jácome, Tácito do Nascimento, Monteiro, Maria Goretti Lins, Luz, Kleber Giovanni
Format: Report
Language:English
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Summary:Visceral leishmaniasis is a systemic disease that is potentially severe and endemic in Brazil. It clinically manifests as fever, weight loss, swelling, hepatosplenomegaly, paleness, and edema. In this study, we discuss a case of a 1-year-old child diagnosed with refractory visceral leishmaniasis after being treated with liposomal amphotericin B in two distinct occasions. Considering the persistent clinical features and weak response to conventional treatment, a combination therapy with liposomal amphotericin B (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate was initiated, and response to treatment was good.
ISSN:1678-9849
DOI:10.1590/0037-8682-0398-2017