Rapid Optimization of Reaction Conditions Based on Comprehensive Reaction Analysis Using a Continuous Flow Microwave Reactor

Generally, the flow method has the advantage of a precise control over the reaction parameters and a facile modification of the reaction conditions, while a continuous flow microwave reactor allows for the quick optimization of reaction conditions owing to the rapid uniform heating. In this study, w...

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Bibliographic Details
Published in:Chemical record 2019-01, Vol.19 (1), p.77-84
Main Authors: Vámosi, Péter, Matsuo, Keiya, Masuda, Tsuguya, Sato, Kohei, Narumi, Tetsuo, Takeda, Kazuhiro, Mase, Nobuyuki
Format: Article
Language:English
Subjects:
Acylation
Continuous flow
design of experiments
flow synthesis
microwave chemistry
Optimization
Organic chemistry
Parameter modification
Reactors
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Summary:Generally, the flow method has the advantage of a precise control over the reaction parameters and a facile modification of the reaction conditions, while a continuous flow microwave reactor allows for the quick optimization of reaction conditions owing to the rapid uniform heating. In this study, we developed a “9+4+1 method” to optimize reaction conditions based on comprehensive reaction analysis using a flow microwave reactor. The proposed method is expected to contribute to the synthesis of various fine and bulk chemicals by reducing cost and wastage, and by conserving time. A continuous flow microwave reactor has the potential for quick optimization of reaction conditions owing to the rapid uniform heating. In this study, we developed a “9+4+1 method” to optimize reaction conditions based on comprehensive reaction analysis using a flow microwave reactor. Our proposed method would facilitate industrial production of various fine and bulk chemicals without wastage and in a short time.
ISSN:1527-8999
1528-0691
DOI:10.1002/tcr.201800048