Histological changes in immune and endocrine organs of quail embryos: Exposure to estrogen and nonylphenol

Effects of 17 β-estradiol and p-nonylphenol were examined in the immune and endocrine organs of Japanese quail embryos. The test compounds were injected into the yolk of embryonated eggs. Injection of estrogen resulted in (1) disappearance of lymphoid cells and flattened development of plicae in the...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 2006-11, Vol.65 (3), p.364-371
Main Authors: Razia, Sultana, Maegawa, Yukari, Tamotsu, Satoshi, Oishi, Tadashi
Format: Article
Language:English
Subjects:
Animal, plant and microbial ecology
Animals
Applied ecology
Aves
Biological and medical sciences
Bursa of Fabricius - drug effects
Bursa of Fabricius - pathology
Coturnix
Coturnix japonica
Ecotoxicology, biological effects of pollution
Effects of pollution and side effects of pesticides on vertebrates
Embryo
Endocrine organ
Estradiol - toxicity
Estrogen
Feminization - chemically induced
Fundamental and applied biological sciences. Psychology
Immune organ
Japanese quail
Male
Nonylphenol
Ovotestis
Phenols - toxicity
Quail - embryology
Testis - drug effects
Testis - pathology
Thymus Gland - drug effects
Thymus Gland - pathology
Thyroid Gland - drug effects
Thyroid Gland - pathology
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Summary:Effects of 17 β-estradiol and p-nonylphenol were examined in the immune and endocrine organs of Japanese quail embryos. The test compounds were injected into the yolk of embryonated eggs. Injection of estrogen resulted in (1) disappearance of lymphoid cells and flattened development of plicae in the bursa of Fabricius, (2) decreased area of thyroid follicles and height of simple cuboidal epithelial cells in the thyroid, (3) increased follicular appearance of the thymus, and (4) development of an ovotestis in male embryos. Injection of nonylphenol did not induce flattened plicae in the bursa of Fabricius or development of an ovotestis in male embryos, but it increased the disappearance of lymphoid cells from the lymphoid follicles in the bursa, decreased the height of simple cuboidal epithelial cells surrounding the thyroid follicle, and increased the follicle-like structure in the thymus in male embryos. These results suggest that nonylphenol has estrogenic effects, but these are low compared to those of estrogen itself.
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2005.07.026