The INCA System: A Further Step Towards a Telemedical Artificial Pancreas

Biomedical engineering research efforts have accomplished another level of a ldquotechnological solutionrdquo for diabetes: an artificial pancreas to be used by patients and supervised by healthcare professionals at any time and place. Reliability of continuous glucose monitoring, availability of re...

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Bibliographic Details
Published in:IEEE journal of biomedical and health informatics 2008-07, Vol.12 (4), p.470-479
Main Authors: Gomez, E.J., Perez, M.E.H., Vering, T., Rigla Cros, M., Bott, O., Garcia-Saez, G., Pretschner, P., Brugues, E., Schnell, O., Patte, C., Bergmann, J., Dudde, R., de Leiva, A.
Format: Article
Language:English
Subjects:
Artificial pancreas
Bioartificial Organs
Biomedical engineering
Biomedical monitoring
Blood Glucose Self-Monitoring - instrumentation
Computer Systems
Computers, Handheld
Control systems
Diabetes
Diabetes Mellitus - drug therapy
Equipment Design
Equipment Failure Analysis
Insulin
Insulin Infusion Systems
Medical control systems
Pancreas
Patient monitoring
Self Administration - instrumentation
Self Administration - methods
smart assistant
Sugar
Telemedicine
Telemedicine - instrumentation
Therapy, Computer-Assisted - instrumentation
Therapy, Computer-Assisted - methods
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Summary:Biomedical engineering research efforts have accomplished another level of a ldquotechnological solutionrdquo for diabetes: an artificial pancreas to be used by patients and supervised by healthcare professionals at any time and place. Reliability of continuous glucose monitoring, availability of real-time programmable insulin pumps, and validation of safe and efficient control algorithms are critical components for achieving that goal. Nevertheless, the development and integration of these new technologies within a telemedicine system can be the basis of a future artificial pancreas. This paper introduces the concept, design, and evaluation of the ldquointelligent control assistant for diabetes, INCArdquo system. INCA is a personal digital assistant (PDA)-based personal smart assistant to provide patients with closed-loop control strategies (personal and remote loop), based on a real-time continuous glucose sensor (Guardian RT, Medtronic), an insulin pump (D-TRON, Disetronic Medical Systems), and a mobile general packet radio service (GPRS)-based telemedicine communication system. Patient therapeutic decision making is supervised by doctors through a multiaccess telemedicine central server that provides to diabetics and doctors a Web-based access to continuous glucose monitoring and insulin infusion data. The INCA system has been technically and clinically evaluated in two randomized and crossover clinical trials showing an improvement on glycaemic control of diabetic patients.
ISSN:1089-7771
2168-2194
1558-0032
2168-2208
DOI:10.1109/TITB.2007.902162